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Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota

Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large number of complex studies of the immune system focusing on tumor cell recognition have revealed new insights and strategies developed, largely through major histocompatibility complexes (MHCs). As one of them,...

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Autores principales: Wen, Minting, Li, Yingjing, Qin, Xiaonan, Qin, Bing, Wang, Qiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378520/
https://www.ncbi.nlm.nih.gov/pubmed/37508545
http://dx.doi.org/10.3390/cells12141882
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author Wen, Minting
Li, Yingjing
Qin, Xiaonan
Qin, Bing
Wang, Qiong
author_facet Wen, Minting
Li, Yingjing
Qin, Xiaonan
Qin, Bing
Wang, Qiong
author_sort Wen, Minting
collection PubMed
description Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large number of complex studies of the immune system focusing on tumor cell recognition have revealed new insights and strategies developed, largely through major histocompatibility complexes (MHCs). As one of them, tumor-specific MHC-II expression (tsMHC-II) can facilitate immune surveillance to detect tumor antigens, and thereby has been used in immunotherapy, including superior cancer prognosis, clinical sensitivity to immune checkpoint inhibition (ICI) therapy and tumor-bearing rejection in mice. NK cells play a unique role in enhancing innate immune responses, accounting for part of the response including immunosurveillance and immunoregulation. NK cells are also capable of initiating the response of the adaptive immune system to cancer immunotherapy independent of cytotoxic T cells, clearly demonstrating a link between NK cell function and the efficacy of cancer immunotherapies. Eosinophils were shown to feature pleiotropic activities against a variety of solid tumor types, including direct interactions with tumor cells, and accessorily affect immunotherapeutic response through intricating cross-talk with lymphocytes. Additionally, microbial sequencing and reconstitution revealed that commensal microbiota might be involved in the modulation of cancer progression, including positive and negative regulatory bacteria. They may play functional roles in not only mucosal modulation, but also systemic immune responses. Here, we present a panorama of the cancer immune network mediated by MHCI/II molecules, immune cells and commensal microbiota and a discussion of prospective relevant intervening mechanisms involved in cancer immunotherapies.
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spelling pubmed-103785202023-07-29 Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota Wen, Minting Li, Yingjing Qin, Xiaonan Qin, Bing Wang, Qiong Cells Review Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large number of complex studies of the immune system focusing on tumor cell recognition have revealed new insights and strategies developed, largely through major histocompatibility complexes (MHCs). As one of them, tumor-specific MHC-II expression (tsMHC-II) can facilitate immune surveillance to detect tumor antigens, and thereby has been used in immunotherapy, including superior cancer prognosis, clinical sensitivity to immune checkpoint inhibition (ICI) therapy and tumor-bearing rejection in mice. NK cells play a unique role in enhancing innate immune responses, accounting for part of the response including immunosurveillance and immunoregulation. NK cells are also capable of initiating the response of the adaptive immune system to cancer immunotherapy independent of cytotoxic T cells, clearly demonstrating a link between NK cell function and the efficacy of cancer immunotherapies. Eosinophils were shown to feature pleiotropic activities against a variety of solid tumor types, including direct interactions with tumor cells, and accessorily affect immunotherapeutic response through intricating cross-talk with lymphocytes. Additionally, microbial sequencing and reconstitution revealed that commensal microbiota might be involved in the modulation of cancer progression, including positive and negative regulatory bacteria. They may play functional roles in not only mucosal modulation, but also systemic immune responses. Here, we present a panorama of the cancer immune network mediated by MHCI/II molecules, immune cells and commensal microbiota and a discussion of prospective relevant intervening mechanisms involved in cancer immunotherapies. MDPI 2023-07-18 /pmc/articles/PMC10378520/ /pubmed/37508545 http://dx.doi.org/10.3390/cells12141882 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wen, Minting
Li, Yingjing
Qin, Xiaonan
Qin, Bing
Wang, Qiong
Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title_full Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title_fullStr Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title_full_unstemmed Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title_short Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota
title_sort insight into cancer immunity: mhcs, immune cells and commensal microbiota
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378520/
https://www.ncbi.nlm.nih.gov/pubmed/37508545
http://dx.doi.org/10.3390/cells12141882
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