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The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities

Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 chi...

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Autores principales: Basoli, Stefano, Cosentino, Monica, Traversari, Matteo, Manfrini, Marco, Tsukamoto, Shinji, Mavrogenis, Andreas F., Bordini, Barbara, Donati, Davide Maria, Errani, Costantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378558/
https://www.ncbi.nlm.nih.gov/pubmed/37504371
http://dx.doi.org/10.3390/curroncol30070511
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author Basoli, Stefano
Cosentino, Monica
Traversari, Matteo
Manfrini, Marco
Tsukamoto, Shinji
Mavrogenis, Andreas F.
Bordini, Barbara
Donati, Davide Maria
Errani, Costantino
author_facet Basoli, Stefano
Cosentino, Monica
Traversari, Matteo
Manfrini, Marco
Tsukamoto, Shinji
Mavrogenis, Andreas F.
Bordini, Barbara
Donati, Davide Maria
Errani, Costantino
author_sort Basoli, Stefano
collection PubMed
description Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 children who were treated for appendicular osteosarcoma, including patient age and sex, tumor site and size (≥8 cm or <8 cm), presence of metastasis, chemotherapy-induced tumor necrosis, serum levels of alkaline phosphatase (AP), C-reactive protein, serum hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate (ESR), leukocyte counts, platelet count, and neutrophil–lymphocyte ratio. Results: A multivariate Cox regression model showed that high level of AP [HR of 1.73; 95% CI, 1.02 to 2.94], poor chemotherapy-induced tumor necrosis [HR of 2.40; 95% CI, 1.41 to 4.08] and presence of metastases at presentation [HR of 3.71; 95% CI, 2.19 to 6.29] were associated with poor prognosis at 5 years (p < 0.05). Inadequate surgical margins [HR 11.28; 95% CI, 1.37 to 92.79] and high levels of ESR [HR 3.58; 95% CI, 1.29 to 9.98] showed a greater risk of local recurrence at 5 years follow-up (p < 0.05). Conclusions: AP and ESR can identify osteosarcoma-diagnosed children with a greater risk of death and local recurrence, respectively.
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spelling pubmed-103785582023-07-29 The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities Basoli, Stefano Cosentino, Monica Traversari, Matteo Manfrini, Marco Tsukamoto, Shinji Mavrogenis, Andreas F. Bordini, Barbara Donati, Davide Maria Errani, Costantino Curr Oncol Article Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 children who were treated for appendicular osteosarcoma, including patient age and sex, tumor site and size (≥8 cm or <8 cm), presence of metastasis, chemotherapy-induced tumor necrosis, serum levels of alkaline phosphatase (AP), C-reactive protein, serum hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate (ESR), leukocyte counts, platelet count, and neutrophil–lymphocyte ratio. Results: A multivariate Cox regression model showed that high level of AP [HR of 1.73; 95% CI, 1.02 to 2.94], poor chemotherapy-induced tumor necrosis [HR of 2.40; 95% CI, 1.41 to 4.08] and presence of metastases at presentation [HR of 3.71; 95% CI, 2.19 to 6.29] were associated with poor prognosis at 5 years (p < 0.05). Inadequate surgical margins [HR 11.28; 95% CI, 1.37 to 92.79] and high levels of ESR [HR 3.58; 95% CI, 1.29 to 9.98] showed a greater risk of local recurrence at 5 years follow-up (p < 0.05). Conclusions: AP and ESR can identify osteosarcoma-diagnosed children with a greater risk of death and local recurrence, respectively. MDPI 2023-07-24 /pmc/articles/PMC10378558/ /pubmed/37504371 http://dx.doi.org/10.3390/curroncol30070511 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Basoli, Stefano
Cosentino, Monica
Traversari, Matteo
Manfrini, Marco
Tsukamoto, Shinji
Mavrogenis, Andreas F.
Bordini, Barbara
Donati, Davide Maria
Errani, Costantino
The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title_full The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title_fullStr The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title_full_unstemmed The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title_short The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
title_sort prognostic value of serum biomarkers for survival of children with osteosarcoma of the extremities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378558/
https://www.ncbi.nlm.nih.gov/pubmed/37504371
http://dx.doi.org/10.3390/curroncol30070511
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