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The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 chi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378558/ https://www.ncbi.nlm.nih.gov/pubmed/37504371 http://dx.doi.org/10.3390/curroncol30070511 |
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author | Basoli, Stefano Cosentino, Monica Traversari, Matteo Manfrini, Marco Tsukamoto, Shinji Mavrogenis, Andreas F. Bordini, Barbara Donati, Davide Maria Errani, Costantino |
author_facet | Basoli, Stefano Cosentino, Monica Traversari, Matteo Manfrini, Marco Tsukamoto, Shinji Mavrogenis, Andreas F. Bordini, Barbara Donati, Davide Maria Errani, Costantino |
author_sort | Basoli, Stefano |
collection | PubMed |
description | Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 children who were treated for appendicular osteosarcoma, including patient age and sex, tumor site and size (≥8 cm or <8 cm), presence of metastasis, chemotherapy-induced tumor necrosis, serum levels of alkaline phosphatase (AP), C-reactive protein, serum hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate (ESR), leukocyte counts, platelet count, and neutrophil–lymphocyte ratio. Results: A multivariate Cox regression model showed that high level of AP [HR of 1.73; 95% CI, 1.02 to 2.94], poor chemotherapy-induced tumor necrosis [HR of 2.40; 95% CI, 1.41 to 4.08] and presence of metastases at presentation [HR of 3.71; 95% CI, 2.19 to 6.29] were associated with poor prognosis at 5 years (p < 0.05). Inadequate surgical margins [HR 11.28; 95% CI, 1.37 to 92.79] and high levels of ESR [HR 3.58; 95% CI, 1.29 to 9.98] showed a greater risk of local recurrence at 5 years follow-up (p < 0.05). Conclusions: AP and ESR can identify osteosarcoma-diagnosed children with a greater risk of death and local recurrence, respectively. |
format | Online Article Text |
id | pubmed-10378558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103785582023-07-29 The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities Basoli, Stefano Cosentino, Monica Traversari, Matteo Manfrini, Marco Tsukamoto, Shinji Mavrogenis, Andreas F. Bordini, Barbara Donati, Davide Maria Errani, Costantino Curr Oncol Article Background: Osteosarcoma is a highly aggressive malignant bone tumor that affects mainly adolescents and young adults. We analyzed serum biomarkers for their prognostic significance in children with osteosarcoma. Methods: In this retrospective study, we investigated the prognostic factors in 210 children who were treated for appendicular osteosarcoma, including patient age and sex, tumor site and size (≥8 cm or <8 cm), presence of metastasis, chemotherapy-induced tumor necrosis, serum levels of alkaline phosphatase (AP), C-reactive protein, serum hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate (ESR), leukocyte counts, platelet count, and neutrophil–lymphocyte ratio. Results: A multivariate Cox regression model showed that high level of AP [HR of 1.73; 95% CI, 1.02 to 2.94], poor chemotherapy-induced tumor necrosis [HR of 2.40; 95% CI, 1.41 to 4.08] and presence of metastases at presentation [HR of 3.71; 95% CI, 2.19 to 6.29] were associated with poor prognosis at 5 years (p < 0.05). Inadequate surgical margins [HR 11.28; 95% CI, 1.37 to 92.79] and high levels of ESR [HR 3.58; 95% CI, 1.29 to 9.98] showed a greater risk of local recurrence at 5 years follow-up (p < 0.05). Conclusions: AP and ESR can identify osteosarcoma-diagnosed children with a greater risk of death and local recurrence, respectively. MDPI 2023-07-24 /pmc/articles/PMC10378558/ /pubmed/37504371 http://dx.doi.org/10.3390/curroncol30070511 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Basoli, Stefano Cosentino, Monica Traversari, Matteo Manfrini, Marco Tsukamoto, Shinji Mavrogenis, Andreas F. Bordini, Barbara Donati, Davide Maria Errani, Costantino The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title | The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title_full | The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title_fullStr | The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title_full_unstemmed | The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title_short | The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities |
title_sort | prognostic value of serum biomarkers for survival of children with osteosarcoma of the extremities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378558/ https://www.ncbi.nlm.nih.gov/pubmed/37504371 http://dx.doi.org/10.3390/curroncol30070511 |
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