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Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia
H. pylori (ubiquitous) and anemia together represent one of the growing health concerns globally. Gastroduodenal sequelae of H. pylori infection are distinguished; however, for the H. pylori infection and its implication in the development of anemia, iron has a significant health impact. We aimed to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378611/ https://www.ncbi.nlm.nih.gov/pubmed/37510148 http://dx.doi.org/10.3390/diagnostics13142404 |
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author | Al Mutawa, Omar A. Izhari, Mohammad Asrar Alharbi, Raed A. Sindi, Abdulmajeed Abdulghani A. Alqarni, Abdullah M. Alotaibi, Foton E. Gosady, Ahmed R. A. Dardari, Daifallah M. M. Almutairi, Abdulrahman M. Alshehri, Mohammed Athathi, Ahmed I. E. |
author_facet | Al Mutawa, Omar A. Izhari, Mohammad Asrar Alharbi, Raed A. Sindi, Abdulmajeed Abdulghani A. Alqarni, Abdullah M. Alotaibi, Foton E. Gosady, Ahmed R. A. Dardari, Daifallah M. M. Almutairi, Abdulrahman M. Alshehri, Mohammed Athathi, Ahmed I. E. |
author_sort | Al Mutawa, Omar A. |
collection | PubMed |
description | H. pylori (ubiquitous) and anemia together represent one of the growing health concerns globally. Gastroduodenal sequelae of H. pylori infection are distinguished; however, for the H. pylori infection and its implication in the development of anemia, iron has a significant health impact. We aimed to evaluate H. pylori infection-associated anemia by employing a logistic regression analysis model. A retrospective (case–control) study design-based assessment of the H. pylori associated-anemia. The study area was geo-referenced by QGIS/QuickMapServies. Descriptive and inferential statistical analyses were accomplished using the R-base–R-studio (v-4.0.2)-tidyverse. A p-value < 0.05 was the statistical significance cut-off value. A ggplot2 package was used for data representation and visualization. Mean ± SD age, Hb, MCV, ferritin, and RBC for overall study participants were measured to be 44.0 ± 13.58, 13.84 ± 2.49, 83.02 ± 8.31, 59.42 ± 68.37, and 5.14 ± 0.75, respectively. Decreased levels of Hb (infected vs. uninfected: 13.26 ± 2.92 vs. 14.42 ± 1.75, p < 0.001) ferritin (infected vs. uninfected: 48.11 ± 63.75 vs. 71.17 ± 71.14, p < 0.001), and MCV (infected vs. uninfected: 81.29 ± 9.13 vs. and 84.82 ± 6.93, p < 0.05) were measured to be associated with H. pylori infection when compared with H. pylori uninfected control group. Moreover, the magnitude (prevalence) of anemia (infected vs. uninfected: 78% vs. 21%, p < 0.001), iron deficiency anemia (IDA) (infected vs. uninfected: 63.3% vs. 36.6%, p < 0.001), and microcytic anemia (infected vs. uninfected: 71.6% vs. 46.1%, p < 0.001) were significantly different among the H. pylori-infected participants. The higher likelihood of developing anemia (AOR; 4.98, 95% CI; 3.089–8.308, p < 0.001), IDA (AOR; 3.061, 95% CI; 2.135–4.416, p < 0.001), and microcytic anemia (AOR; 3.289, 95% CI; 2.213–4.949, p < 0.001) by 398%, 206.1%, and 229%, respectively, was associated with H. pylori-infected. We recommend the regular monitoring of hematological parameters and eradication of H. pylori infection to minimize the extra-gastric health consequences of H. pylori infection. |
format | Online Article Text |
id | pubmed-10378611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103786112023-07-29 Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia Al Mutawa, Omar A. Izhari, Mohammad Asrar Alharbi, Raed A. Sindi, Abdulmajeed Abdulghani A. Alqarni, Abdullah M. Alotaibi, Foton E. Gosady, Ahmed R. A. Dardari, Daifallah M. M. Almutairi, Abdulrahman M. Alshehri, Mohammed Athathi, Ahmed I. E. Diagnostics (Basel) Article H. pylori (ubiquitous) and anemia together represent one of the growing health concerns globally. Gastroduodenal sequelae of H. pylori infection are distinguished; however, for the H. pylori infection and its implication in the development of anemia, iron has a significant health impact. We aimed to evaluate H. pylori infection-associated anemia by employing a logistic regression analysis model. A retrospective (case–control) study design-based assessment of the H. pylori associated-anemia. The study area was geo-referenced by QGIS/QuickMapServies. Descriptive and inferential statistical analyses were accomplished using the R-base–R-studio (v-4.0.2)-tidyverse. A p-value < 0.05 was the statistical significance cut-off value. A ggplot2 package was used for data representation and visualization. Mean ± SD age, Hb, MCV, ferritin, and RBC for overall study participants were measured to be 44.0 ± 13.58, 13.84 ± 2.49, 83.02 ± 8.31, 59.42 ± 68.37, and 5.14 ± 0.75, respectively. Decreased levels of Hb (infected vs. uninfected: 13.26 ± 2.92 vs. 14.42 ± 1.75, p < 0.001) ferritin (infected vs. uninfected: 48.11 ± 63.75 vs. 71.17 ± 71.14, p < 0.001), and MCV (infected vs. uninfected: 81.29 ± 9.13 vs. and 84.82 ± 6.93, p < 0.05) were measured to be associated with H. pylori infection when compared with H. pylori uninfected control group. Moreover, the magnitude (prevalence) of anemia (infected vs. uninfected: 78% vs. 21%, p < 0.001), iron deficiency anemia (IDA) (infected vs. uninfected: 63.3% vs. 36.6%, p < 0.001), and microcytic anemia (infected vs. uninfected: 71.6% vs. 46.1%, p < 0.001) were significantly different among the H. pylori-infected participants. The higher likelihood of developing anemia (AOR; 4.98, 95% CI; 3.089–8.308, p < 0.001), IDA (AOR; 3.061, 95% CI; 2.135–4.416, p < 0.001), and microcytic anemia (AOR; 3.289, 95% CI; 2.213–4.949, p < 0.001) by 398%, 206.1%, and 229%, respectively, was associated with H. pylori-infected. We recommend the regular monitoring of hematological parameters and eradication of H. pylori infection to minimize the extra-gastric health consequences of H. pylori infection. MDPI 2023-07-18 /pmc/articles/PMC10378611/ /pubmed/37510148 http://dx.doi.org/10.3390/diagnostics13142404 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Al Mutawa, Omar A. Izhari, Mohammad Asrar Alharbi, Raed A. Sindi, Abdulmajeed Abdulghani A. Alqarni, Abdullah M. Alotaibi, Foton E. Gosady, Ahmed R. A. Dardari, Daifallah M. M. Almutairi, Abdulrahman M. Alshehri, Mohammed Athathi, Ahmed I. E. Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title | Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title_full | Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title_fullStr | Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title_full_unstemmed | Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title_short | Helicobacter pylori (H. pylori) Infection-Associated Anemia in the Asir Region, Saudi Arabia |
title_sort | helicobacter pylori (h. pylori) infection-associated anemia in the asir region, saudi arabia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378611/ https://www.ncbi.nlm.nih.gov/pubmed/37510148 http://dx.doi.org/10.3390/diagnostics13142404 |
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