Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature

Myasthenia gravis (MG) is one of the most common neuromuscular adverse effects of immune checkpoint inhibitors (ICIs) and can result in significant morbidity and mortality when it affects the bulbar and respiratory muscles. Diagnosing immune-related MG (irMG) is challenging due to its nonspecific pr...

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Detalles Bibliográficos
Autores principales: Eglenen Polat, Buse, Safi, Danish, Hafez, Maria, Kamran, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378713/
https://www.ncbi.nlm.nih.gov/pubmed/37519591
http://dx.doi.org/10.7759/cureus.41087
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author Eglenen Polat, Buse
Safi, Danish
Hafez, Maria
Kamran, Amir
author_facet Eglenen Polat, Buse
Safi, Danish
Hafez, Maria
Kamran, Amir
author_sort Eglenen Polat, Buse
collection PubMed
description Myasthenia gravis (MG) is one of the most common neuromuscular adverse effects of immune checkpoint inhibitors (ICIs) and can result in significant morbidity and mortality when it affects the bulbar and respiratory muscles. Diagnosing immune-related MG (irMG) is challenging due to its nonspecific presentation and high negativity rate for MG antibody markers. Patients, primary care providers, and emergency care providers should be educated about MG as a potential adverse effect of ICIs for timely diagnosis and intervention.
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spelling pubmed-103787132023-07-29 Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature Eglenen Polat, Buse Safi, Danish Hafez, Maria Kamran, Amir Cureus Internal Medicine Myasthenia gravis (MG) is one of the most common neuromuscular adverse effects of immune checkpoint inhibitors (ICIs) and can result in significant morbidity and mortality when it affects the bulbar and respiratory muscles. Diagnosing immune-related MG (irMG) is challenging due to its nonspecific presentation and high negativity rate for MG antibody markers. Patients, primary care providers, and emergency care providers should be educated about MG as a potential adverse effect of ICIs for timely diagnosis and intervention. Cureus 2023-06-28 /pmc/articles/PMC10378713/ /pubmed/37519591 http://dx.doi.org/10.7759/cureus.41087 Text en Copyright © 2023, Eglenen Polat et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Eglenen Polat, Buse
Safi, Danish
Hafez, Maria
Kamran, Amir
Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title_full Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title_fullStr Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title_full_unstemmed Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title_short Pembrolizumab-Induced Myasthenia Gravis: A Case Report and Review of the Literature
title_sort pembrolizumab-induced myasthenia gravis: a case report and review of the literature
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378713/
https://www.ncbi.nlm.nih.gov/pubmed/37519591
http://dx.doi.org/10.7759/cureus.41087
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