Cargando…

Protocol Report on the Transcranial Photobiomodulation for Alzheimer’s Disease (TRAP-AD) Study

Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral cortex, stimulates the mitochondrial respiratory chain...

Descripción completa

Detalles Bibliográficos
Autores principales: Iosifescu, Dan V., Song, Xiaotong, Gersten, Maia B., Adib, Arwa, Cho, Yoonju, Collins, Katherine M., Yates, Kathy F., Hurtado-Puerto, Aura M., McEachern, Kayla M., Osorio, Ricardo S., Cassano, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378818/
https://www.ncbi.nlm.nih.gov/pubmed/37510458
http://dx.doi.org/10.3390/healthcare11142017
Descripción
Sumario:Background: Alzheimer’s disease’s (AD) prevalence is projected to increase as the population ages and current treatments are minimally effective. Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light penetrates into the cerebral cortex, stimulates the mitochondrial respiratory chain, and increases cerebral blood flow. Preliminary data suggests t-PBM may be efficacious in improving cognition in people with early AD and amnestic mild cognitive impairment (aMCI). Methods: In this randomized, double-blind, placebo-controlled study with aMCI and early AD participants, we will test the efficacy, safety, and impact on cognition of 24 sessions of t-PBM delivered over 8 weeks. Brain mechanisms of t-PBM in this population will be explored by testing whether the baseline tau burden (measured with (18)F-MK6240), or changes in mitochondrial function over 8 weeks (assessed with (31)P-MRSI), moderates the changes observed in cognitive functions after t-PBM therapy. We will also use changes in the fMRI Blood-Oxygenation-Level-Dependent (BOLD) signal after a single treatment to demonstrate t-PBM-dependent increases in prefrontal cortex blood flow. Conclusion: This study will test whether t-PBM, a low-cost, accessible, and user-friendly intervention, has the potential to improve cognition and function in an aMCI and early AD population.