2-Methoxyestradiol-3,17-O,O-bis-sulfamate (STX140) Inhibits Proliferation and Invasion via Senescence Pathway Induction in Human BRAFi-Resistant Melanoma Cells

The endogenous estradiol derivative 2-Methoxyestradiol (2-ME) has shown good and wide anticancer activity but suffers from poor oral bioavailability and extensive metabolic conjugation. However, its sulfamoylated derivative, 2-methoxyestradiol-3,17-O,O-bis-sulfamate (STX140), has superior potential...

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Detalles Bibliográficos
Autores principales: Franco, Ylana Adami, de Moraes, Manoel Oliveira, Carvalho, Larissa A. C., Dohle, Wolfgang, da Silva, Renaira Oliveira, Noma, Isabella Harumi Yonehara, Lima, Keli, Potter, Barry V. L., Machado-Neto, João A., Maria-Engler, Silvya Stuchi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378825/
https://www.ncbi.nlm.nih.gov/pubmed/37511073
http://dx.doi.org/10.3390/ijms241411314

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