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Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis
As our understanding of the biologic basis of acute myeloid leukemia evolves, so do the classification systems used to describe this group of cancers. Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic technologies...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378849/ https://www.ncbi.nlm.nih.gov/pubmed/37510328 http://dx.doi.org/10.3390/genes14071424 |
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author | Demir, Derya |
author_facet | Demir, Derya |
author_sort | Demir, Derya |
collection | PubMed |
description | As our understanding of the biologic basis of acute myeloid leukemia evolves, so do the classification systems used to describe this group of cancers. Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic technologies has led to rapid growth in our understanding of these diseases and thus the refinement of classification systems. Recently, two new systems, the International Consensus Classification system and the 5th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues, were published to incorporate the latest genomic advances in blood cancer. This article reviews the major updates in acute myeloid leukemia in both systems and highlights the biologic insights that have driven these changes. |
format | Online Article Text |
id | pubmed-10378849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103788492023-07-29 Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis Demir, Derya Genes (Basel) Review As our understanding of the biologic basis of acute myeloid leukemia evolves, so do the classification systems used to describe this group of cancers. Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic technologies has led to rapid growth in our understanding of these diseases and thus the refinement of classification systems. Recently, two new systems, the International Consensus Classification system and the 5th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues, were published to incorporate the latest genomic advances in blood cancer. This article reviews the major updates in acute myeloid leukemia in both systems and highlights the biologic insights that have driven these changes. MDPI 2023-07-10 /pmc/articles/PMC10378849/ /pubmed/37510328 http://dx.doi.org/10.3390/genes14071424 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Demir, Derya Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title | Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title_full | Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title_fullStr | Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title_full_unstemmed | Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title_short | Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis |
title_sort | insights into the new molecular updates in acute myeloid leukemia pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378849/ https://www.ncbi.nlm.nih.gov/pubmed/37510328 http://dx.doi.org/10.3390/genes14071424 |
work_keys_str_mv | AT demirderya insightsintothenewmolecularupdatesinacutemyeloidleukemiapathogenesis |