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Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects

This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally i...

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Autores principales: Piergentili, Roberto, Gullo, Giuseppe, Basile, Giuseppe, Gulia, Caterina, Porrello, Alessandro, Cucinella, Gaspare, Marinelli, Enrico, Zaami, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379073/
https://www.ncbi.nlm.nih.gov/pubmed/37511115
http://dx.doi.org/10.3390/ijms241411356
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author Piergentili, Roberto
Gullo, Giuseppe
Basile, Giuseppe
Gulia, Caterina
Porrello, Alessandro
Cucinella, Gaspare
Marinelli, Enrico
Zaami, Simona
author_facet Piergentili, Roberto
Gullo, Giuseppe
Basile, Giuseppe
Gulia, Caterina
Porrello, Alessandro
Cucinella, Gaspare
Marinelli, Enrico
Zaami, Simona
author_sort Piergentili, Roberto
collection PubMed
description This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally invasive characterization of the health and fertility parameters of the patient, together with the concerns regarding the obstetric, neonatal, and adult health risks of the children conceived via assisted reproductive techniques (ART) are all essential aspects of the problem to be taken into consideration, yet the possibility to harmonize such needs through a concerted and integrated approach is still very challenging. This review aims to illustrate the main features of EC and how it affects the normal physiology of pre-menopausal women. We also focus on the prospect of a miR-based, molecular evaluation of patient health status, including both EC early diagnosis and staging and, similarly, the receptivity of the woman, discussing the possible evaluation of both aspects using a single specific panel of circulating miRs in the patient, thus allowing a relatively fast, non-invasive testing with a significantly reduced margin of error. Finally, the ethical and legal/regulatory aspects of such innovative techniques require not only a risk-benefit analysis; respect for patient autonomy and equitable health care access allocation are fundamental issues as well.
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spelling pubmed-103790732023-07-29 Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects Piergentili, Roberto Gullo, Giuseppe Basile, Giuseppe Gulia, Caterina Porrello, Alessandro Cucinella, Gaspare Marinelli, Enrico Zaami, Simona Int J Mol Sci Review This review article explores the possibility of developing an integrated approach to the management of the different needs of endometrial cancer (EC) patients seeking to become pregnant. Life preservation of the woman, health preservation of the baby, a precocious and—as much as possible—minimally invasive characterization of the health and fertility parameters of the patient, together with the concerns regarding the obstetric, neonatal, and adult health risks of the children conceived via assisted reproductive techniques (ART) are all essential aspects of the problem to be taken into consideration, yet the possibility to harmonize such needs through a concerted and integrated approach is still very challenging. This review aims to illustrate the main features of EC and how it affects the normal physiology of pre-menopausal women. We also focus on the prospect of a miR-based, molecular evaluation of patient health status, including both EC early diagnosis and staging and, similarly, the receptivity of the woman, discussing the possible evaluation of both aspects using a single specific panel of circulating miRs in the patient, thus allowing a relatively fast, non-invasive testing with a significantly reduced margin of error. Finally, the ethical and legal/regulatory aspects of such innovative techniques require not only a risk-benefit analysis; respect for patient autonomy and equitable health care access allocation are fundamental issues as well. MDPI 2023-07-12 /pmc/articles/PMC10379073/ /pubmed/37511115 http://dx.doi.org/10.3390/ijms241411356 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Piergentili, Roberto
Gullo, Giuseppe
Basile, Giuseppe
Gulia, Caterina
Porrello, Alessandro
Cucinella, Gaspare
Marinelli, Enrico
Zaami, Simona
Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title_full Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title_fullStr Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title_full_unstemmed Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title_short Circulating miRNAs as a Tool for Early Diagnosis of Endometrial Cancer—Implications for the Fertility-Sparing Process: Clinical, Biological, and Legal Aspects
title_sort circulating mirnas as a tool for early diagnosis of endometrial cancer—implications for the fertility-sparing process: clinical, biological, and legal aspects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379073/
https://www.ncbi.nlm.nih.gov/pubmed/37511115
http://dx.doi.org/10.3390/ijms241411356
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