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Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report

Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious age...

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Autores principales: Vergov, Bozhidar, Angelova, Andreana, Baldzhieva, Alexandra, Kalchev, Yordan, Tsochev, Georgi, Murdjeva, Marianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379339/
https://www.ncbi.nlm.nih.gov/pubmed/37510501
http://dx.doi.org/10.3390/healthcare11142059
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author Vergov, Bozhidar
Angelova, Andreana
Baldzhieva, Alexandra
Kalchev, Yordan
Tsochev, Georgi
Murdjeva, Marianna
author_facet Vergov, Bozhidar
Angelova, Andreana
Baldzhieva, Alexandra
Kalchev, Yordan
Tsochev, Georgi
Murdjeva, Marianna
author_sort Vergov, Bozhidar
collection PubMed
description Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious agent—Gordonia sputi. In recent years, the incidence of Gordonia spp. infections in immunocompromised patients with central venous catheters (CVC) has appeared to rise. The isolation and identification of Gordonia spp. are challenging and require modern techniques. In addition, the treatment is usually persistent and often results in CVC extraction, which is associated with further risk and costs for the patient. We also studied the alterations in the immune status of the patient caused by long-term renal replacement therapy and persistent hepatitis C virus infection. Antibiotic therapy and immunostimulation with Inosine pranobex lead to successful eradication of the infection without the need for CVC replacement.
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spelling pubmed-103793392023-07-29 Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report Vergov, Bozhidar Angelova, Andreana Baldzhieva, Alexandra Kalchev, Yordan Tsochev, Georgi Murdjeva, Marianna Healthcare (Basel) Case Report Improvements in medical care have turned severe diseases into chronic conditions, but often their treatment and the use of medical devices are related to specific complications. Here, we present a clinical case of a long-term dialysis patient who was infected with a rare opportunistic infectious agent—Gordonia sputi. In recent years, the incidence of Gordonia spp. infections in immunocompromised patients with central venous catheters (CVC) has appeared to rise. The isolation and identification of Gordonia spp. are challenging and require modern techniques. In addition, the treatment is usually persistent and often results in CVC extraction, which is associated with further risk and costs for the patient. We also studied the alterations in the immune status of the patient caused by long-term renal replacement therapy and persistent hepatitis C virus infection. Antibiotic therapy and immunostimulation with Inosine pranobex lead to successful eradication of the infection without the need for CVC replacement. MDPI 2023-07-19 /pmc/articles/PMC10379339/ /pubmed/37510501 http://dx.doi.org/10.3390/healthcare11142059 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Vergov, Bozhidar
Angelova, Andreana
Baldzhieva, Alexandra
Kalchev, Yordan
Tsochev, Georgi
Murdjeva, Marianna
Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title_full Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title_fullStr Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title_full_unstemmed Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title_short Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report
title_sort gordonia sputi as an arising causative agent of bacteremia in immunocompromised comorbid dialysis patients—a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379339/
https://www.ncbi.nlm.nih.gov/pubmed/37510501
http://dx.doi.org/10.3390/healthcare11142059
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