Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells

MicroRNAs (miRNAs), small non-coding RNA molecules, regulate a wide range of critical biological processes, such as proliferation, cell cycle progression, differentiation, survival, and apoptosis, in many cell types. The regulatory functions of miRNAs in embryogenesis and stem cell properties have b...

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Autores principales: Maraghechi, Pouneh, Aponte, Maria Teresa Salinas, Ecker, András, Lázár, Bence, Tóth, Roland, Szabadi, Nikolett Tokodyné, Gócza, Elen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379376/
https://www.ncbi.nlm.nih.gov/pubmed/37510338
http://dx.doi.org/10.3390/genes14071434
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author Maraghechi, Pouneh
Aponte, Maria Teresa Salinas
Ecker, András
Lázár, Bence
Tóth, Roland
Szabadi, Nikolett Tokodyné
Gócza, Elen
author_facet Maraghechi, Pouneh
Aponte, Maria Teresa Salinas
Ecker, András
Lázár, Bence
Tóth, Roland
Szabadi, Nikolett Tokodyné
Gócza, Elen
author_sort Maraghechi, Pouneh
collection PubMed
description MicroRNAs (miRNAs), small non-coding RNA molecules, regulate a wide range of critical biological processes, such as proliferation, cell cycle progression, differentiation, survival, and apoptosis, in many cell types. The regulatory functions of miRNAs in embryogenesis and stem cell properties have been extensively investigated since the early years of miRNA discovery. In this review, we will compare and discuss the impact of stem-cell-specific miRNA clusters on the maintenance and regulation of early embryonic development, pluripotency, and self-renewal of embryonic stem cells, particularly in vertebrates.
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spelling pubmed-103793762023-07-29 Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells Maraghechi, Pouneh Aponte, Maria Teresa Salinas Ecker, András Lázár, Bence Tóth, Roland Szabadi, Nikolett Tokodyné Gócza, Elen Genes (Basel) Review MicroRNAs (miRNAs), small non-coding RNA molecules, regulate a wide range of critical biological processes, such as proliferation, cell cycle progression, differentiation, survival, and apoptosis, in many cell types. The regulatory functions of miRNAs in embryogenesis and stem cell properties have been extensively investigated since the early years of miRNA discovery. In this review, we will compare and discuss the impact of stem-cell-specific miRNA clusters on the maintenance and regulation of early embryonic development, pluripotency, and self-renewal of embryonic stem cells, particularly in vertebrates. MDPI 2023-07-12 /pmc/articles/PMC10379376/ /pubmed/37510338 http://dx.doi.org/10.3390/genes14071434 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maraghechi, Pouneh
Aponte, Maria Teresa Salinas
Ecker, András
Lázár, Bence
Tóth, Roland
Szabadi, Nikolett Tokodyné
Gócza, Elen
Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title_full Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title_fullStr Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title_full_unstemmed Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title_short Pluripotency-Associated microRNAs in Early Vertebrate Embryos and Stem Cells
title_sort pluripotency-associated micrornas in early vertebrate embryos and stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379376/
https://www.ncbi.nlm.nih.gov/pubmed/37510338
http://dx.doi.org/10.3390/genes14071434
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