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Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis
Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells h...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379580/ https://www.ncbi.nlm.nih.gov/pubmed/37511144 http://dx.doi.org/10.3390/ijms241411385 |
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author | Cavalcante-Silva, Luiz Henrique Agra Almeida, Fernanda Silva de Andrade, Arthur Gomes Comberlang, Fernando Cézar Cardoso, Leonardo Lima Vanderley, Shayenne Eduarda Ramos Keesen, Tatjana S. L. |
author_facet | Cavalcante-Silva, Luiz Henrique Agra Almeida, Fernanda Silva de Andrade, Arthur Gomes Comberlang, Fernando Cézar Cardoso, Leonardo Lima Vanderley, Shayenne Eduarda Ramos Keesen, Tatjana S. L. |
author_sort | Cavalcante-Silva, Luiz Henrique Agra |
collection | PubMed |
description | Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target. |
format | Online Article Text |
id | pubmed-10379580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103795802023-07-29 Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis Cavalcante-Silva, Luiz Henrique Agra Almeida, Fernanda Silva de Andrade, Arthur Gomes Comberlang, Fernando Cézar Cardoso, Leonardo Lima Vanderley, Shayenne Eduarda Ramos Keesen, Tatjana S. L. Int J Mol Sci Review Mycobacterium tuberculosis complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target. MDPI 2023-07-13 /pmc/articles/PMC10379580/ /pubmed/37511144 http://dx.doi.org/10.3390/ijms241411385 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cavalcante-Silva, Luiz Henrique Agra Almeida, Fernanda Silva de Andrade, Arthur Gomes Comberlang, Fernando Cézar Cardoso, Leonardo Lima Vanderley, Shayenne Eduarda Ramos Keesen, Tatjana S. L. Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title | Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title_full | Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title_fullStr | Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title_full_unstemmed | Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title_short | Mycobacterium tuberculosis in a Trap: The Role of Neutrophil Extracellular Traps in Tuberculosis |
title_sort | mycobacterium tuberculosis in a trap: the role of neutrophil extracellular traps in tuberculosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379580/ https://www.ncbi.nlm.nih.gov/pubmed/37511144 http://dx.doi.org/10.3390/ijms241411385 |
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