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Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release

The use of a controlled-release drug carrier is an innovative solution for the treatment of local infections, in particular in dentistry, skin diseases, and in open wounds. The biocompatibility, biodegradability, the possibility of a large amount of drug adsorbed (especially those with hydrophilic p...

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Detalles Bibliográficos
Autores principales: Trusek, Anna, Grabowski, Maciej, Ajayi, Omoyemi, Kijak, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379592/
https://www.ncbi.nlm.nih.gov/pubmed/37504405
http://dx.doi.org/10.3390/gels9070526
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author Trusek, Anna
Grabowski, Maciej
Ajayi, Omoyemi
Kijak, Edward
author_facet Trusek, Anna
Grabowski, Maciej
Ajayi, Omoyemi
Kijak, Edward
author_sort Trusek, Anna
collection PubMed
description The use of a controlled-release drug carrier is an innovative solution for the treatment of local infections, in particular in dentistry, skin diseases, and in open wounds. The biocompatibility, biodegradability, the possibility of a large amount of drug adsorbed (especially those with hydrophilic properties), and the ability to create structures of any shape and size are the reasons for hydrogels to be frequently studied. The main disadvantage of hydrogel carriers is the rapid rate of drug release; hence, in this study, an attempt was made to additionally chemically cross-link 1-ethyl-3-(3-dimethyl aminopropyl)-1-carbodiimide hydrochloride (EDC) with the hyaluronic acid–alginate (HA–SAL) structure. The answer to significantly reduce the mass flux typical for hydrogel structure was to surround it with a polymer layer using a dry cover. By coating the carriers with polylactide, the release time was increased by around forty times. As the carriers were designed to reduce local bacterial infections, among others in dentistry, the released antibiotics were amoxycillin, metronidazole, and doxycycline.
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spelling pubmed-103795922023-07-29 Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release Trusek, Anna Grabowski, Maciej Ajayi, Omoyemi Kijak, Edward Gels Article The use of a controlled-release drug carrier is an innovative solution for the treatment of local infections, in particular in dentistry, skin diseases, and in open wounds. The biocompatibility, biodegradability, the possibility of a large amount of drug adsorbed (especially those with hydrophilic properties), and the ability to create structures of any shape and size are the reasons for hydrogels to be frequently studied. The main disadvantage of hydrogel carriers is the rapid rate of drug release; hence, in this study, an attempt was made to additionally chemically cross-link 1-ethyl-3-(3-dimethyl aminopropyl)-1-carbodiimide hydrochloride (EDC) with the hyaluronic acid–alginate (HA–SAL) structure. The answer to significantly reduce the mass flux typical for hydrogel structure was to surround it with a polymer layer using a dry cover. By coating the carriers with polylactide, the release time was increased by around forty times. As the carriers were designed to reduce local bacterial infections, among others in dentistry, the released antibiotics were amoxycillin, metronidazole, and doxycycline. MDPI 2023-06-28 /pmc/articles/PMC10379592/ /pubmed/37504405 http://dx.doi.org/10.3390/gels9070526 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trusek, Anna
Grabowski, Maciej
Ajayi, Omoyemi
Kijak, Edward
Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title_full Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title_fullStr Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title_full_unstemmed Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title_short Hyaluronic Acid–Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release
title_sort hyaluronic acid–alginate homogeneous structures with polylactide coating applied in controlled antibiotic release
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379592/
https://www.ncbi.nlm.nih.gov/pubmed/37504405
http://dx.doi.org/10.3390/gels9070526
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