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Decidual macrophages derived NO downregulates PD-L1 in trophoblasts leading to decreased Treg cells in recurrent miscarriage

INTRODUCTION: Placental trophoblasts contribute to regulatory T (Treg) function via the programmed cell death-1 (PD-1)/PD-1 ligand 1 (PD-L1) pathway during normal pregnancy. Decreased expression of PD-L1 in trophoblasts was closely associated with Treg deficiency in the development of pregnancy fail...

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Detalles Bibliográficos
Autores principales:	Zhang, Yonghong, Wang, Huiyan, Qiu, Panpan, Jiang, Jingwen, Wu, Xuhong, Mei, Jie, Sun, Haixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379637/ https://www.ncbi.nlm.nih.gov/pubmed/37520550 http://dx.doi.org/10.3389/fimmu.2023.1180154

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