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The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants
The independent effects of deceased donor kidney length and vascular plaque on long-term graft survival are not established. Utilizing DonorNet attachments from 4,480 expanded criteria donors (ECD) recovered between 2008 and 2012 in the United States with at least one kidney biopsied and transplante...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379651/ https://www.ncbi.nlm.nih.gov/pubmed/37519905 http://dx.doi.org/10.3389/ti.2023.11373 |
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author | Tanriover, Bekir Stewart, Darren Kamal, Layla Saeed, Muhammad Cooper, Matthew Foutz, Julia McGehee, Harrison Gupta, Gaurav |
author_facet | Tanriover, Bekir Stewart, Darren Kamal, Layla Saeed, Muhammad Cooper, Matthew Foutz, Julia McGehee, Harrison Gupta, Gaurav |
author_sort | Tanriover, Bekir |
collection | PubMed |
description | The independent effects of deceased donor kidney length and vascular plaque on long-term graft survival are not established. Utilizing DonorNet attachments from 4,480 expanded criteria donors (ECD) recovered between 2008 and 2012 in the United States with at least one kidney biopsied and transplanted, we analyzed the relationship between kidney length and vascular plaques and 10-year hazard of all-cause graft failure (ACGF) using causal inference methods in a Cox regression framework. The composite plaque score (range 0–4) and the presence of any plaque (yes, no) was also analyzed. Kidney length was modeled both categorically (<10, 10–12, >12 cm) as well as numerically, using a restricted cubic spline to capture nonlinearity. Effects of a novel composite plaque score 4 vs. 0 (HR 1.08; 95% CI: 0.96, 1.23) and the presence of any vascular plaque (HR 1.08; 95% CI: 0.98, 1.20) were attenuated after adjustment. Likewise, we identified a potential nonlinear relationship between kidney length and the 10-year hazard of ACGF, however the strength of the relationship was attenuated after adjusting for other donor factors. The independent effects of vascular plaque and kidney length on long-term ECD graft survival were found to be minimal and should not play a significant role in utilization. |
format | Online Article Text |
id | pubmed-10379651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103796512023-07-29 The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants Tanriover, Bekir Stewart, Darren Kamal, Layla Saeed, Muhammad Cooper, Matthew Foutz, Julia McGehee, Harrison Gupta, Gaurav Transpl Int Health Archive The independent effects of deceased donor kidney length and vascular plaque on long-term graft survival are not established. Utilizing DonorNet attachments from 4,480 expanded criteria donors (ECD) recovered between 2008 and 2012 in the United States with at least one kidney biopsied and transplanted, we analyzed the relationship between kidney length and vascular plaques and 10-year hazard of all-cause graft failure (ACGF) using causal inference methods in a Cox regression framework. The composite plaque score (range 0–4) and the presence of any plaque (yes, no) was also analyzed. Kidney length was modeled both categorically (<10, 10–12, >12 cm) as well as numerically, using a restricted cubic spline to capture nonlinearity. Effects of a novel composite plaque score 4 vs. 0 (HR 1.08; 95% CI: 0.96, 1.23) and the presence of any vascular plaque (HR 1.08; 95% CI: 0.98, 1.20) were attenuated after adjustment. Likewise, we identified a potential nonlinear relationship between kidney length and the 10-year hazard of ACGF, however the strength of the relationship was attenuated after adjusting for other donor factors. The independent effects of vascular plaque and kidney length on long-term ECD graft survival were found to be minimal and should not play a significant role in utilization. Frontiers Media S.A. 2023-07-14 /pmc/articles/PMC10379651/ /pubmed/37519905 http://dx.doi.org/10.3389/ti.2023.11373 Text en Copyright © 2023 Tanriover, Stewart, Kamal, Saeed, Cooper, Foutz, McGehee and Gupta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Health Archive Tanriover, Bekir Stewart, Darren Kamal, Layla Saeed, Muhammad Cooper, Matthew Foutz, Julia McGehee, Harrison Gupta, Gaurav The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title | The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title_full | The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title_fullStr | The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title_full_unstemmed | The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title_short | The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants |
title_sort | independent effects of kidney length and vascular plaque on ten-year outcomes of extended criteria donor kidney transplants |
topic | Health Archive |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379651/ https://www.ncbi.nlm.nih.gov/pubmed/37519905 http://dx.doi.org/10.3389/ti.2023.11373 |
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