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Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome?
BACKGROUND: Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Babol University of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379793/ https://www.ncbi.nlm.nih.gov/pubmed/37520875 http://dx.doi.org/10.22088/cjim.14.3.567 |
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author | Omrani-Nava, Versa Moosazadeh, Mahmood Bahar, Adeleh Hedayatizadeh-Omran, Akbar Ahmadi, Abdolrahim Alizadeh-Navaei, Reza |
author_facet | Omrani-Nava, Versa Moosazadeh, Mahmood Bahar, Adeleh Hedayatizadeh-Omran, Akbar Ahmadi, Abdolrahim Alizadeh-Navaei, Reza |
author_sort | Omrani-Nava, Versa |
collection | PubMed |
description | BACKGROUND: Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios serve as prognostic biomarkers for metabolic syndrome (MetS). This hypothesis was investigated in a cohort of the Iranian population. METHODS: selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study. RESULTS: A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66±0.71 vs. 1.69±0.72 P=0.42), LMR (11.23±3.13 vs. 11.30±11.99, P= 0.86) and PLR (113.85±68.67 vs 114.11±35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI. CONCLUSION: In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS. |
format | Online Article Text |
id | pubmed-10379793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-103797932023-07-29 Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? Omrani-Nava, Versa Moosazadeh, Mahmood Bahar, Adeleh Hedayatizadeh-Omran, Akbar Ahmadi, Abdolrahim Alizadeh-Navaei, Reza Caspian J Intern Med Short Communication BACKGROUND: Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios serve as prognostic biomarkers for metabolic syndrome (MetS). This hypothesis was investigated in a cohort of the Iranian population. METHODS: selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study. RESULTS: A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66±0.71 vs. 1.69±0.72 P=0.42), LMR (11.23±3.13 vs. 11.30±11.99, P= 0.86) and PLR (113.85±68.67 vs 114.11±35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI. CONCLUSION: In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS. Babol University of Medical Sciences 2023 /pmc/articles/PMC10379793/ /pubmed/37520875 http://dx.doi.org/10.22088/cjim.14.3.567 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Omrani-Nava, Versa Moosazadeh, Mahmood Bahar, Adeleh Hedayatizadeh-Omran, Akbar Ahmadi, Abdolrahim Alizadeh-Navaei, Reza Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title | Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title_full | Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title_fullStr | Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title_full_unstemmed | Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title_short | Neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
title_sort | neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios, any association with metabolic syndrome? |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379793/ https://www.ncbi.nlm.nih.gov/pubmed/37520875 http://dx.doi.org/10.22088/cjim.14.3.567 |
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