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Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa

Retinal angiomatous proliferation (RAP) and other types of choroidal neovascularization (CNV) are very rarely reported in patients with retinitis pigmentosa (RP). We present a case report of a 91-year-old patient with an obvious RP phenotype, who presented with a sudden onset of vision worsening and...

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Autores principales: Kiraly, Peter, Downes, Susan M., Fischer, M. Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379935/
https://www.ncbi.nlm.nih.gov/pubmed/37510342
http://dx.doi.org/10.3390/genes14071438
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author Kiraly, Peter
Downes, Susan M.
Fischer, M. Dominik
author_facet Kiraly, Peter
Downes, Susan M.
Fischer, M. Dominik
author_sort Kiraly, Peter
collection PubMed
description Retinal angiomatous proliferation (RAP) and other types of choroidal neovascularization (CNV) are very rarely reported in patients with retinitis pigmentosa (RP). We present a case report of a 91-year-old patient with an obvious RP phenotype, who presented with a sudden onset of vision worsening and metamorphopsia in the left eye. Genetic testing on the UK inherited retinal disease panel did not identify a pathogenic variant. Multimodal imaging comprising optical coherence tomography (OCT), OCT angiography, and fluorescein and indocyanine green angiography showed a RAP lesion in the left macula. The patient received three treatments of monthly injections of aflibercept, with excellent morphological and functional outcomes. Taking into account the patient’s age at presentation of the RAP lesion, it is not clear whether the RAP was associated or coincidental with RP. This case report highlights the importance of possessing an awareness that RAP lesions can occur in RP. Moreover, due to a good response and potential safety concerns with continuous anti-VEGF injections in RP patients, a pro re nata (PRN) regimen might be the safest option.
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spelling pubmed-103799352023-07-29 Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa Kiraly, Peter Downes, Susan M. Fischer, M. Dominik Genes (Basel) Case Report Retinal angiomatous proliferation (RAP) and other types of choroidal neovascularization (CNV) are very rarely reported in patients with retinitis pigmentosa (RP). We present a case report of a 91-year-old patient with an obvious RP phenotype, who presented with a sudden onset of vision worsening and metamorphopsia in the left eye. Genetic testing on the UK inherited retinal disease panel did not identify a pathogenic variant. Multimodal imaging comprising optical coherence tomography (OCT), OCT angiography, and fluorescein and indocyanine green angiography showed a RAP lesion in the left macula. The patient received three treatments of monthly injections of aflibercept, with excellent morphological and functional outcomes. Taking into account the patient’s age at presentation of the RAP lesion, it is not clear whether the RAP was associated or coincidental with RP. This case report highlights the importance of possessing an awareness that RAP lesions can occur in RP. Moreover, due to a good response and potential safety concerns with continuous anti-VEGF injections in RP patients, a pro re nata (PRN) regimen might be the safest option. MDPI 2023-07-13 /pmc/articles/PMC10379935/ /pubmed/37510342 http://dx.doi.org/10.3390/genes14071438 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kiraly, Peter
Downes, Susan M.
Fischer, M. Dominik
Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title_full Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title_fullStr Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title_full_unstemmed Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title_short Retinal Angiomatous Proliferation in a Patient with Retinitis Pigmentosa
title_sort retinal angiomatous proliferation in a patient with retinitis pigmentosa
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379935/
https://www.ncbi.nlm.nih.gov/pubmed/37510342
http://dx.doi.org/10.3390/genes14071438
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