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The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications
The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with endothelial d...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380219/ https://www.ncbi.nlm.nih.gov/pubmed/37511615 http://dx.doi.org/10.3390/ijms241411854 |
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author | Drysdale, Amelia Unsworth, Amanda J. White, Stephen J. Jones, Sarah |
author_facet | Drysdale, Amelia Unsworth, Amanda J. White, Stephen J. Jones, Sarah |
author_sort | Drysdale, Amelia |
collection | PubMed |
description | The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with endothelial dysfunction and has been implicated in the development and progression of atherosclerosis. The ECM composition of atherosclerotic plaques varies depending on plaque phenotype and vulnerability, with distinct differences observed between ruptured and erodes plaques. Moreover, the thrombi on the exposed ECM are diverse in structure and composition, suggesting that the best antithrombotic approach may differ depending on plaque phenotype. This review provides a comprehensive overview of the role of proteoglycans in atherogenesis and thrombosis. It discusses the differential expression of the proteoglycans in different plaque phenotypes and the potential impact on platelet function and thrombosis. Finally, the review highlights the importance of this concept in developing a targeted approach to antithrombotic treatments to improve clinical outcomes in cardiovascular disease. |
format | Online Article Text |
id | pubmed-10380219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103802192023-07-29 The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications Drysdale, Amelia Unsworth, Amanda J. White, Stephen J. Jones, Sarah Int J Mol Sci Review The vascular extracellular matrix (ECM) produced by endothelial and smooth muscle cells is composed of collagens and glycoproteins and plays an integral role in regulating the structure and function of the vascular wall. Alteration in the expression of these proteins is associated with endothelial dysfunction and has been implicated in the development and progression of atherosclerosis. The ECM composition of atherosclerotic plaques varies depending on plaque phenotype and vulnerability, with distinct differences observed between ruptured and erodes plaques. Moreover, the thrombi on the exposed ECM are diverse in structure and composition, suggesting that the best antithrombotic approach may differ depending on plaque phenotype. This review provides a comprehensive overview of the role of proteoglycans in atherogenesis and thrombosis. It discusses the differential expression of the proteoglycans in different plaque phenotypes and the potential impact on platelet function and thrombosis. Finally, the review highlights the importance of this concept in developing a targeted approach to antithrombotic treatments to improve clinical outcomes in cardiovascular disease. MDPI 2023-07-24 /pmc/articles/PMC10380219/ /pubmed/37511615 http://dx.doi.org/10.3390/ijms241411854 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Drysdale, Amelia Unsworth, Amanda J. White, Stephen J. Jones, Sarah The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title | The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title_full | The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title_fullStr | The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title_full_unstemmed | The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title_short | The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications |
title_sort | contribution of vascular proteoglycans to atherothrombosis: clinical implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380219/ https://www.ncbi.nlm.nih.gov/pubmed/37511615 http://dx.doi.org/10.3390/ijms241411854 |
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