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Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy

HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP...

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Autores principales: Romanidou, Gioulia, Konstantinidis, Theocharis G., Natsi, Anastasia-Maria, Kantartzi, Konstantia, Panopoulou, Maria, Kontomanolis, Emmanouil, Tsigalou, Christina, Lambropoulou, Maria, Gavriilaki, Eleni, Panagoutsos, Stylianos, Pasadakis, Ploumis, Mitroulis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380227/
https://www.ncbi.nlm.nih.gov/pubmed/37511523
http://dx.doi.org/10.3390/ijms241411762
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author Romanidou, Gioulia
Konstantinidis, Theocharis G.
Natsi, Anastasia-Maria
Kantartzi, Konstantia
Panopoulou, Maria
Kontomanolis, Emmanouil
Tsigalou, Christina
Lambropoulou, Maria
Gavriilaki, Eleni
Panagoutsos, Stylianos
Pasadakis, Ploumis
Mitroulis, Ioannis
author_facet Romanidou, Gioulia
Konstantinidis, Theocharis G.
Natsi, Anastasia-Maria
Kantartzi, Konstantia
Panopoulou, Maria
Kontomanolis, Emmanouil
Tsigalou, Christina
Lambropoulou, Maria
Gavriilaki, Eleni
Panagoutsos, Stylianos
Pasadakis, Ploumis
Mitroulis, Ioannis
author_sort Romanidou, Gioulia
collection PubMed
description HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated.
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spelling pubmed-103802272023-07-29 Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy Romanidou, Gioulia Konstantinidis, Theocharis G. Natsi, Anastasia-Maria Kantartzi, Konstantia Panopoulou, Maria Kontomanolis, Emmanouil Tsigalou, Christina Lambropoulou, Maria Gavriilaki, Eleni Panagoutsos, Stylianos Pasadakis, Ploumis Mitroulis, Ioannis Int J Mol Sci Communication HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated. MDPI 2023-07-21 /pmc/articles/PMC10380227/ /pubmed/37511523 http://dx.doi.org/10.3390/ijms241411762 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Romanidou, Gioulia
Konstantinidis, Theocharis G.
Natsi, Anastasia-Maria
Kantartzi, Konstantia
Panopoulou, Maria
Kontomanolis, Emmanouil
Tsigalou, Christina
Lambropoulou, Maria
Gavriilaki, Eleni
Panagoutsos, Stylianos
Pasadakis, Ploumis
Mitroulis, Ioannis
Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title_full Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title_fullStr Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title_full_unstemmed Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title_short Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
title_sort decreased levels of soluble developmental endothelial locus-1 are associated with thrombotic microangiopathy in pregnancy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380227/
https://www.ncbi.nlm.nih.gov/pubmed/37511523
http://dx.doi.org/10.3390/ijms241411762
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