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Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy
HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380227/ https://www.ncbi.nlm.nih.gov/pubmed/37511523 http://dx.doi.org/10.3390/ijms241411762 |
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author | Romanidou, Gioulia Konstantinidis, Theocharis G. Natsi, Anastasia-Maria Kantartzi, Konstantia Panopoulou, Maria Kontomanolis, Emmanouil Tsigalou, Christina Lambropoulou, Maria Gavriilaki, Eleni Panagoutsos, Stylianos Pasadakis, Ploumis Mitroulis, Ioannis |
author_facet | Romanidou, Gioulia Konstantinidis, Theocharis G. Natsi, Anastasia-Maria Kantartzi, Konstantia Panopoulou, Maria Kontomanolis, Emmanouil Tsigalou, Christina Lambropoulou, Maria Gavriilaki, Eleni Panagoutsos, Stylianos Pasadakis, Ploumis Mitroulis, Ioannis |
author_sort | Romanidou, Gioulia |
collection | PubMed |
description | HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated. |
format | Online Article Text |
id | pubmed-10380227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103802272023-07-29 Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy Romanidou, Gioulia Konstantinidis, Theocharis G. Natsi, Anastasia-Maria Kantartzi, Konstantia Panopoulou, Maria Kontomanolis, Emmanouil Tsigalou, Christina Lambropoulou, Maria Gavriilaki, Eleni Panagoutsos, Stylianos Pasadakis, Ploumis Mitroulis, Ioannis Int J Mol Sci Communication HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) syndrome is a life-threatening complication of pregnancy, which is often secondary to preeclampsia. To date, there is no biomarker in clinical use for the early stratification of women with preeclampsia who are under increased risk of HELLP syndrome. Herein, we show that the levels of circulating developmental endothelial locus-1 (DEL-1), which is an extracellular immunomodulatory protein, are decreased in patients with HELLP syndrome compared to preeclampsia. DEL-1 levels are also negatively correlated with the circulating levels of kidney injury molecule-1 (KIM-1), which is a biomarker for disorders associated with kidney damage. Receiver-operating characteristic curve analysis for DEL-1 levels and the DEL-1 to KIM-1 ratio demonstrates that these values could be used as a potential biomarker that distinguishes patients with HELLP syndrome and preeclampsia. Finally, we show that placental endothelial cells are a source for DEL-1, and that the expression of this protein in placenta from patients with HELLP syndrome is minimal. Taken together, this study shows that DEL-1 is downregulated in HELLP syndrome both in the circulation and at the affected placental tissue, suggesting a potential role for this protein as a biomarker, which must be further evaluated. MDPI 2023-07-21 /pmc/articles/PMC10380227/ /pubmed/37511523 http://dx.doi.org/10.3390/ijms241411762 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Romanidou, Gioulia Konstantinidis, Theocharis G. Natsi, Anastasia-Maria Kantartzi, Konstantia Panopoulou, Maria Kontomanolis, Emmanouil Tsigalou, Christina Lambropoulou, Maria Gavriilaki, Eleni Panagoutsos, Stylianos Pasadakis, Ploumis Mitroulis, Ioannis Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title | Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title_full | Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title_fullStr | Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title_full_unstemmed | Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title_short | Decreased Levels of Soluble Developmental Endothelial Locus-1 Are Associated with Thrombotic Microangiopathy in Pregnancy |
title_sort | decreased levels of soluble developmental endothelial locus-1 are associated with thrombotic microangiopathy in pregnancy |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380227/ https://www.ncbi.nlm.nih.gov/pubmed/37511523 http://dx.doi.org/10.3390/ijms241411762 |
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