Integrative Multi-Omics Analysis of Oncogenic EZH2 Mutants: From Epigenetic Reprogramming to Molecular Signatures

Somatic heterozygous mutations in the active site of the enhancer of zeste homolog 2 (EZH2) are prevalent in diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML). The methyltransferase activity of EZH2 towards lysine 27 on histone H3 (H3K27) and non-histone proteins is dysregulated...

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Detalles Bibliográficos
Autores principales: Aldana, Julian, Gardner, Miranda L., Freitas, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380343/
https://www.ncbi.nlm.nih.gov/pubmed/37511137
http://dx.doi.org/10.3390/ijms241411378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380343/
https://www.ncbi.nlm.nih.gov/pubmed/37511137
http://dx.doi.org/10.3390/ijms241411378

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