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Frontotemporal Dementia, Where Do We Stand? A Narrative Review
Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and emotional burden for the patients and caregivers. It is characterised by a (at least initially) selective degeneration o...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380352/ https://www.ncbi.nlm.nih.gov/pubmed/37511491 http://dx.doi.org/10.3390/ijms241411732 |
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author | Antonioni, Annibale Raho, Emanuela Maria Lopriore, Piervito Pace, Antonia Pia Latino, Raffaela Rita Assogna, Martina Mancuso, Michelangelo Gragnaniello, Daniela Granieri, Enrico Pugliatti, Maura Di Lorenzo, Francesco Koch, Giacomo |
author_facet | Antonioni, Annibale Raho, Emanuela Maria Lopriore, Piervito Pace, Antonia Pia Latino, Raffaela Rita Assogna, Martina Mancuso, Michelangelo Gragnaniello, Daniela Granieri, Enrico Pugliatti, Maura Di Lorenzo, Francesco Koch, Giacomo |
author_sort | Antonioni, Annibale |
collection | PubMed |
description | Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and emotional burden for the patients and caregivers. It is characterised by a (at least initially) selective degeneration of the frontal and/or temporal lobe, generally leading to behavioural alterations, speech disorders, and psychiatric symptoms. Despite the recent advances, given its extreme heterogeneity, an overview that can bring together all the data currently available is still lacking. Here, we aim to provide a state of the art on the pathogenesis of this disease, starting with established findings and integrating them with more recent ones. In particular, advances in the genetics field will be examined, assessing them in relation to both the clinical manifestations and histopathological findings, as well as considering the link with other diseases, such as amyotrophic lateral sclerosis (ALS). Furthermore, the current diagnostic criteria will be explored, including neuroimaging methods, nuclear medicine investigations, and biomarkers on biological fluids. Of note, the promising information provided by neurophysiological investigations, i.e., electroencephalography and non-invasive brain stimulation techniques, concerning the alterations in brain networks and neurotransmitter systems will be reviewed. Finally, current and experimental therapies will be considered. |
format | Online Article Text |
id | pubmed-10380352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103803522023-07-29 Frontotemporal Dementia, Where Do We Stand? A Narrative Review Antonioni, Annibale Raho, Emanuela Maria Lopriore, Piervito Pace, Antonia Pia Latino, Raffaela Rita Assogna, Martina Mancuso, Michelangelo Gragnaniello, Daniela Granieri, Enrico Pugliatti, Maura Di Lorenzo, Francesco Koch, Giacomo Int J Mol Sci Review Frontotemporal dementia (FTD) is a neurodegenerative disease of growing interest, since it accounts for up to 10% of middle-age-onset dementias and entails a social, economic, and emotional burden for the patients and caregivers. It is characterised by a (at least initially) selective degeneration of the frontal and/or temporal lobe, generally leading to behavioural alterations, speech disorders, and psychiatric symptoms. Despite the recent advances, given its extreme heterogeneity, an overview that can bring together all the data currently available is still lacking. Here, we aim to provide a state of the art on the pathogenesis of this disease, starting with established findings and integrating them with more recent ones. In particular, advances in the genetics field will be examined, assessing them in relation to both the clinical manifestations and histopathological findings, as well as considering the link with other diseases, such as amyotrophic lateral sclerosis (ALS). Furthermore, the current diagnostic criteria will be explored, including neuroimaging methods, nuclear medicine investigations, and biomarkers on biological fluids. Of note, the promising information provided by neurophysiological investigations, i.e., electroencephalography and non-invasive brain stimulation techniques, concerning the alterations in brain networks and neurotransmitter systems will be reviewed. Finally, current and experimental therapies will be considered. MDPI 2023-07-21 /pmc/articles/PMC10380352/ /pubmed/37511491 http://dx.doi.org/10.3390/ijms241411732 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Antonioni, Annibale Raho, Emanuela Maria Lopriore, Piervito Pace, Antonia Pia Latino, Raffaela Rita Assogna, Martina Mancuso, Michelangelo Gragnaniello, Daniela Granieri, Enrico Pugliatti, Maura Di Lorenzo, Francesco Koch, Giacomo Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title | Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title_full | Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title_fullStr | Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title_full_unstemmed | Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title_short | Frontotemporal Dementia, Where Do We Stand? A Narrative Review |
title_sort | frontotemporal dementia, where do we stand? a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380352/ https://www.ncbi.nlm.nih.gov/pubmed/37511491 http://dx.doi.org/10.3390/ijms241411732 |
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