Cargando…
Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels wer...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380407/ https://www.ncbi.nlm.nih.gov/pubmed/37504530 http://dx.doi.org/10.3390/jcdd10070274 |
_version_ | 1785080185059540992 |
---|---|
author | Kelly, Conagh J. Chu, Matthew Untaru, Rossana Assadi-Khansari, Bahador Chen, Dongqing Croft, Amanda J. Horowitz, John D. Boyle, Andrew J. Sverdlov, Aaron L. Ngo, Doan T. M. |
author_facet | Kelly, Conagh J. Chu, Matthew Untaru, Rossana Assadi-Khansari, Bahador Chen, Dongqing Croft, Amanda J. Horowitz, John D. Boyle, Andrew J. Sverdlov, Aaron L. Ngo, Doan T. M. |
author_sort | Kelly, Conagh J. |
collection | PubMed |
description | Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/E’ (r = −0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation. |
format | Online Article Text |
id | pubmed-10380407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103804072023-07-29 Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function Kelly, Conagh J. Chu, Matthew Untaru, Rossana Assadi-Khansari, Bahador Chen, Dongqing Croft, Amanda J. Horowitz, John D. Boyle, Andrew J. Sverdlov, Aaron L. Ngo, Doan T. M. J Cardiovasc Dev Dis Communication Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/E’ (r = −0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation. MDPI 2023-06-28 /pmc/articles/PMC10380407/ /pubmed/37504530 http://dx.doi.org/10.3390/jcdd10070274 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Kelly, Conagh J. Chu, Matthew Untaru, Rossana Assadi-Khansari, Bahador Chen, Dongqing Croft, Amanda J. Horowitz, John D. Boyle, Andrew J. Sverdlov, Aaron L. Ngo, Doan T. M. Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title | Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title_full | Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title_fullStr | Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title_full_unstemmed | Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title_short | Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function |
title_sort | association of circulating plasma secreted frizzled-related protein 5 (sfrp5) levels with cardiac function |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380407/ https://www.ncbi.nlm.nih.gov/pubmed/37504530 http://dx.doi.org/10.3390/jcdd10070274 |
work_keys_str_mv | AT kellyconaghj associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT chumatthew associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT untarurossana associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT assadikhansaribahador associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT chendongqing associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT croftamandaj associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT horowitzjohnd associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT boyleandrewj associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT sverdlovaaronl associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction AT ngodoantm associationofcirculatingplasmasecretedfrizzledrelatedprotein5sfrp5levelswithcardiacfunction |