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Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function

Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels wer...

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Autores principales: Kelly, Conagh J., Chu, Matthew, Untaru, Rossana, Assadi-Khansari, Bahador, Chen, Dongqing, Croft, Amanda J., Horowitz, John D., Boyle, Andrew J., Sverdlov, Aaron L., Ngo, Doan T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380407/
https://www.ncbi.nlm.nih.gov/pubmed/37504530
http://dx.doi.org/10.3390/jcdd10070274
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author Kelly, Conagh J.
Chu, Matthew
Untaru, Rossana
Assadi-Khansari, Bahador
Chen, Dongqing
Croft, Amanda J.
Horowitz, John D.
Boyle, Andrew J.
Sverdlov, Aaron L.
Ngo, Doan T. M.
author_facet Kelly, Conagh J.
Chu, Matthew
Untaru, Rossana
Assadi-Khansari, Bahador
Chen, Dongqing
Croft, Amanda J.
Horowitz, John D.
Boyle, Andrew J.
Sverdlov, Aaron L.
Ngo, Doan T. M.
author_sort Kelly, Conagh J.
collection PubMed
description Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/E’ (r = −0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation.
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spelling pubmed-103804072023-07-29 Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function Kelly, Conagh J. Chu, Matthew Untaru, Rossana Assadi-Khansari, Bahador Chen, Dongqing Croft, Amanda J. Horowitz, John D. Boyle, Andrew J. Sverdlov, Aaron L. Ngo, Doan T. M. J Cardiovasc Dev Dis Communication Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that may play a role in cardiovascular development and disease. However, there is yet to be a comprehensive investigation into whether circulating SFRP5 can be a biomarker for cardiac function. Plasma SFRP5 levels were measured via ELISA in 262 patients admitted to a cardiology unit. Plasma SFRP5 levels were significantly lower in patients with a history of heart failure (HF), coronary artery disease (CAD), and atrial fibrillation (AF; p = 0.001). In univariate analyses, SFRP5 levels were also significantly positively correlated with left ventricular ejection fraction (LVEF) (r = 0.52, p < 0.001) and negatively correlated with E/E’ (r = −0.30, p < 0.001). Patients with HF, CAD, low LVEF, low triglycerides, high CRP, and high eGFR were associated with lower SFRP5 levels independent of age, BMI, or diabetes after multivariate analysis (overall model r = 0.729, SE = 0.638). Our results show that low plasma SFRP5 levels are independently associated with the presence of HF, CAD, and, importantly, impaired LV function. These results suggest a potential role of SFRP5 as a biomarker, as well as a mediator of cardiac dysfunction independent of obesity and metabolic regulation. MDPI 2023-06-28 /pmc/articles/PMC10380407/ /pubmed/37504530 http://dx.doi.org/10.3390/jcdd10070274 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kelly, Conagh J.
Chu, Matthew
Untaru, Rossana
Assadi-Khansari, Bahador
Chen, Dongqing
Croft, Amanda J.
Horowitz, John D.
Boyle, Andrew J.
Sverdlov, Aaron L.
Ngo, Doan T. M.
Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title_full Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title_fullStr Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title_full_unstemmed Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title_short Association of Circulating Plasma Secreted Frizzled-Related Protein 5 (Sfrp5) Levels with Cardiac Function
title_sort association of circulating plasma secreted frizzled-related protein 5 (sfrp5) levels with cardiac function
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380407/
https://www.ncbi.nlm.nih.gov/pubmed/37504530
http://dx.doi.org/10.3390/jcdd10070274
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