Bradykinin Metabolism and Drug-Induced Angioedema

Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE. Angiotensin-converting enzyme inhibitors (ACEIs) and neprilysin inhibitors impa...

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Autores principales: Smolinska, Sylwia, Antolín-Amérigo, Darío, Popescu, Florin-Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380452/
https://www.ncbi.nlm.nih.gov/pubmed/37511409
http://dx.doi.org/10.3390/ijms241411649
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author Smolinska, Sylwia
Antolín-Amérigo, Darío
Popescu, Florin-Dan
author_facet Smolinska, Sylwia
Antolín-Amérigo, Darío
Popescu, Florin-Dan
author_sort Smolinska, Sylwia
collection PubMed
description Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE. Angiotensin-converting enzyme inhibitors (ACEIs) and neprilysin inhibitors impair BK catabolism. Dipeptidyl peptidase-IV (DPP-IV) inhibitors reduce the breakdown of BK and substance P (SP). Moreover, angiotensin receptor blockers, thrombolytic agents, and statins may also induce BK-mediated AE. Understanding pathophysiological mechanisms is crucial for preventing and treating drug-induced AE.
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spelling pubmed-103804522023-07-29 Bradykinin Metabolism and Drug-Induced Angioedema Smolinska, Sylwia Antolín-Amérigo, Darío Popescu, Florin-Dan Int J Mol Sci Review Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE. Angiotensin-converting enzyme inhibitors (ACEIs) and neprilysin inhibitors impair BK catabolism. Dipeptidyl peptidase-IV (DPP-IV) inhibitors reduce the breakdown of BK and substance P (SP). Moreover, angiotensin receptor blockers, thrombolytic agents, and statins may also induce BK-mediated AE. Understanding pathophysiological mechanisms is crucial for preventing and treating drug-induced AE. MDPI 2023-07-19 /pmc/articles/PMC10380452/ /pubmed/37511409 http://dx.doi.org/10.3390/ijms241411649 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Smolinska, Sylwia
Antolín-Amérigo, Darío
Popescu, Florin-Dan
Bradykinin Metabolism and Drug-Induced Angioedema
title Bradykinin Metabolism and Drug-Induced Angioedema
title_full Bradykinin Metabolism and Drug-Induced Angioedema
title_fullStr Bradykinin Metabolism and Drug-Induced Angioedema
title_full_unstemmed Bradykinin Metabolism and Drug-Induced Angioedema
title_short Bradykinin Metabolism and Drug-Induced Angioedema
title_sort bradykinin metabolism and drug-induced angioedema
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380452/
https://www.ncbi.nlm.nih.gov/pubmed/37511409
http://dx.doi.org/10.3390/ijms241411649
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