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Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance

FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in cancer development, although its prognostic function remains controversial. In this study, we analyzed the expression of FKBP10 in tumor tissues using online databases (TCGA) as well as our CRC cohort, and investigat...

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Autores principales: Fu, Yating, Chen, Jiahui, Ma, Xianhua, Chang, Wenjun, Zhang, Xiongbao, Liu, Yu, Shen, Hao, Hu, Xuefei, Ren, An-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380463/
https://www.ncbi.nlm.nih.gov/pubmed/37511172
http://dx.doi.org/10.3390/ijms241411415
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author Fu, Yating
Chen, Jiahui
Ma, Xianhua
Chang, Wenjun
Zhang, Xiongbao
Liu, Yu
Shen, Hao
Hu, Xuefei
Ren, An-Jing
author_facet Fu, Yating
Chen, Jiahui
Ma, Xianhua
Chang, Wenjun
Zhang, Xiongbao
Liu, Yu
Shen, Hao
Hu, Xuefei
Ren, An-Jing
author_sort Fu, Yating
collection PubMed
description FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in cancer development, although its prognostic function remains controversial. In this study, we analyzed the expression of FKBP10 in tumor tissues using online databases (TCGA) as well as our CRC cohort, and investigated the relationship between its subcellular expression pattern and patient outcomes. Cox regression analysis was used to determine the associations between different subcellular expression patterns of FKBP10 and clinical features of patients. We also discussed the expression level of FKBP10 based on different subcellular expression patterns. Our results showed that FKBP10 was significantly elevated in CRC tissues and exhibited three different subcellular expression patterns which were defined as ‘FKBP10-C’ (concentrated), ‘FKBP10-T’ (transitional) and ‘FKBP10-D’ (dispersive). The FKBP10-D expression pattern was only found in tumor tissues and was associated with unfavorable disease-free survival in CRC patients. High expression levels of FKBP10-C predicted an unfavorable prognosis of recurrence of CRC, while FKBP10-D did not. Our findings suggest that the subcellular expression patterns and expression level of FKBP10 play crucial prognostic roles in CRC, which revealed that FKBP10 may be a viable prognostic and therapeutic target for the diagnosis and treatment of CRC.
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spelling pubmed-103804632023-07-29 Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance Fu, Yating Chen, Jiahui Ma, Xianhua Chang, Wenjun Zhang, Xiongbao Liu, Yu Shen, Hao Hu, Xuefei Ren, An-Jing Int J Mol Sci Article FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in cancer development, although its prognostic function remains controversial. In this study, we analyzed the expression of FKBP10 in tumor tissues using online databases (TCGA) as well as our CRC cohort, and investigated the relationship between its subcellular expression pattern and patient outcomes. Cox regression analysis was used to determine the associations between different subcellular expression patterns of FKBP10 and clinical features of patients. We also discussed the expression level of FKBP10 based on different subcellular expression patterns. Our results showed that FKBP10 was significantly elevated in CRC tissues and exhibited three different subcellular expression patterns which were defined as ‘FKBP10-C’ (concentrated), ‘FKBP10-T’ (transitional) and ‘FKBP10-D’ (dispersive). The FKBP10-D expression pattern was only found in tumor tissues and was associated with unfavorable disease-free survival in CRC patients. High expression levels of FKBP10-C predicted an unfavorable prognosis of recurrence of CRC, while FKBP10-D did not. Our findings suggest that the subcellular expression patterns and expression level of FKBP10 play crucial prognostic roles in CRC, which revealed that FKBP10 may be a viable prognostic and therapeutic target for the diagnosis and treatment of CRC. MDPI 2023-07-13 /pmc/articles/PMC10380463/ /pubmed/37511172 http://dx.doi.org/10.3390/ijms241411415 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fu, Yating
Chen, Jiahui
Ma, Xianhua
Chang, Wenjun
Zhang, Xiongbao
Liu, Yu
Shen, Hao
Hu, Xuefei
Ren, An-Jing
Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title_full Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title_fullStr Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title_full_unstemmed Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title_short Subcellular Expression Patterns of FKBP Prolyl Isomerase 10 (FKBP10) in Colorectal Cancer and Its Clinical Significance
title_sort subcellular expression patterns of fkbp prolyl isomerase 10 (fkbp10) in colorectal cancer and its clinical significance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380463/
https://www.ncbi.nlm.nih.gov/pubmed/37511172
http://dx.doi.org/10.3390/ijms241411415
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