Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death

Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K(6)[P(2)Mo(18)O(62)] against Escherichia coli (E. coli) O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K(6)[P(2)Mo...

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Autores principales: Lin, Shaoling, Lin, Zhongjing, Zhou, Feng, Wang, Dehua, Zheng, Baodong, Hu, Jiamiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380553/
https://www.ncbi.nlm.nih.gov/pubmed/37511226
http://dx.doi.org/10.3390/ijms241411469
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author Lin, Shaoling
Lin, Zhongjing
Zhou, Feng
Wang, Dehua
Zheng, Baodong
Hu, Jiamiao
author_facet Lin, Shaoling
Lin, Zhongjing
Zhou, Feng
Wang, Dehua
Zheng, Baodong
Hu, Jiamiao
author_sort Lin, Shaoling
collection PubMed
description Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K(6)[P(2)Mo(18)O(62)] against Escherichia coli (E. coli) O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K(6)[P(2)Mo(18)O(62)] could effectively kill E. coli O157:H7 at millimolar levels. Moreover, K(6)[P(2)Mo(18)O(62)] treatment also induced significant increases in recA protein expression and further triggered characteristic apoptosis-like bacterial death events such as DNA fragmentation and phosphatidylserine exposure. In conclusion, polyoxometalate K(6)[P(2)Mo(18)O(62)] possesses a desirable antibacterial activity, and induction of bacterial apoptosis-like death might be involved in its underlying bactericidal mechanisms.
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spelling pubmed-103805532023-07-29 Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death Lin, Shaoling Lin, Zhongjing Zhou, Feng Wang, Dehua Zheng, Baodong Hu, Jiamiao Int J Mol Sci Communication Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K(6)[P(2)Mo(18)O(62)] against Escherichia coli (E. coli) O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K(6)[P(2)Mo(18)O(62)] could effectively kill E. coli O157:H7 at millimolar levels. Moreover, K(6)[P(2)Mo(18)O(62)] treatment also induced significant increases in recA protein expression and further triggered characteristic apoptosis-like bacterial death events such as DNA fragmentation and phosphatidylserine exposure. In conclusion, polyoxometalate K(6)[P(2)Mo(18)O(62)] possesses a desirable antibacterial activity, and induction of bacterial apoptosis-like death might be involved in its underlying bactericidal mechanisms. MDPI 2023-07-14 /pmc/articles/PMC10380553/ /pubmed/37511226 http://dx.doi.org/10.3390/ijms241411469 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lin, Shaoling
Lin, Zhongjing
Zhou, Feng
Wang, Dehua
Zheng, Baodong
Hu, Jiamiao
Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title_full Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title_fullStr Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title_full_unstemmed Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title_short Polyoxometalate K(6)[P(2)Mo(18)O(62)] Inactivates Escherichia coli O157:H7 by Inducing recA Expression and Apoptosis-like Bacterial Death
title_sort polyoxometalate k(6)[p(2)mo(18)o(62)] inactivates escherichia coli o157:h7 by inducing reca expression and apoptosis-like bacterial death
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380553/
https://www.ncbi.nlm.nih.gov/pubmed/37511226
http://dx.doi.org/10.3390/ijms241411469
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