Building Up a Piperazine Ring from a Primary Amino Group via Catalytic Reductive Cyclization of Dioximes

Piperazine is one of the most frequently found scaffolds in small-molecule FDA-approved drugs. In this study, a general approach to the synthesis of piperazines bearing substituents at carbon and nitrogen atoms utilizing primary amines and nitrosoalkenes as synthons was developed. The method relies...

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Detalles Bibliográficos
Autores principales: Pospelov, Evgeny V., Sukhorukov, Alexey Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380651/
https://www.ncbi.nlm.nih.gov/pubmed/37511552
http://dx.doi.org/10.3390/ijms241411794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380651/
https://www.ncbi.nlm.nih.gov/pubmed/37511552
http://dx.doi.org/10.3390/ijms241411794

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