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Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study

Liver disease is often associated with dysfunctional potassium homeostasis but is not a well-established risk factor for hyperkalemia. This retrospective cohort study examined the potential relationship between liver disease and recurrent hyperkalemia. Patients with ≥1 serum potassium measurement be...

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Autores principales: Ahdoot, Rebecca S., Hsiung, Jui-Ting, Agiro, Abiy, Brahmbhatt, Yasmin G., Cooper, Kerry, Fawaz, Souhiela, Westfall, Laura, Kalantar-Zadeh, Kamyar, Streja, Elani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380673/
https://www.ncbi.nlm.nih.gov/pubmed/37510679
http://dx.doi.org/10.3390/jcm12144562
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author Ahdoot, Rebecca S.
Hsiung, Jui-Ting
Agiro, Abiy
Brahmbhatt, Yasmin G.
Cooper, Kerry
Fawaz, Souhiela
Westfall, Laura
Kalantar-Zadeh, Kamyar
Streja, Elani
author_facet Ahdoot, Rebecca S.
Hsiung, Jui-Ting
Agiro, Abiy
Brahmbhatt, Yasmin G.
Cooper, Kerry
Fawaz, Souhiela
Westfall, Laura
Kalantar-Zadeh, Kamyar
Streja, Elani
author_sort Ahdoot, Rebecca S.
collection PubMed
description Liver disease is often associated with dysfunctional potassium homeostasis but is not a well-established risk factor for hyperkalemia. This retrospective cohort study examined the potential relationship between liver disease and recurrent hyperkalemia. Patients with ≥1 serum potassium measurement between January 2004 and December 2018 who experienced hyperkalemia (serum potassium >5.0 mmol/L) were identified from the United States Veterans Affairs database. A competing risk regression model was used to analyze the relationship between patient characteristics and recurrent hyperkalemia. Of 1,493,539 patients with incident hyperkalemia, 71,790 (4.8%) had liver disease (one inpatient or two outpatient records) within 1 year before the index hyperkalemia event. Recurrent hyperkalemia within 1 year after the index event occurred in 234,807 patients (15.7%) overall, 19,518 (27.2%) with liver disease, and 215,289 (15.1%) without liver disease. The risk of recurrent hyperkalemia was significantly increased in patients with liver disease versus those without (subhazard ratio, 1.34; 95% confidence interval, 1.32–1.37; p < 0.0001). Aside from vasodilator therapy, the risk of recurrent hyperkalemia was not increased with concomitant medication. In this cohort study, liver disease was an independent risk factor strongly associated with recurrent hyperkalemia within 1 year, independent of concomitant renin–angiotensin–aldosterone system inhibitor or potassium-sparing diuretic use.
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spelling pubmed-103806732023-07-29 Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study Ahdoot, Rebecca S. Hsiung, Jui-Ting Agiro, Abiy Brahmbhatt, Yasmin G. Cooper, Kerry Fawaz, Souhiela Westfall, Laura Kalantar-Zadeh, Kamyar Streja, Elani J Clin Med Article Liver disease is often associated with dysfunctional potassium homeostasis but is not a well-established risk factor for hyperkalemia. This retrospective cohort study examined the potential relationship between liver disease and recurrent hyperkalemia. Patients with ≥1 serum potassium measurement between January 2004 and December 2018 who experienced hyperkalemia (serum potassium >5.0 mmol/L) were identified from the United States Veterans Affairs database. A competing risk regression model was used to analyze the relationship between patient characteristics and recurrent hyperkalemia. Of 1,493,539 patients with incident hyperkalemia, 71,790 (4.8%) had liver disease (one inpatient or two outpatient records) within 1 year before the index hyperkalemia event. Recurrent hyperkalemia within 1 year after the index event occurred in 234,807 patients (15.7%) overall, 19,518 (27.2%) with liver disease, and 215,289 (15.1%) without liver disease. The risk of recurrent hyperkalemia was significantly increased in patients with liver disease versus those without (subhazard ratio, 1.34; 95% confidence interval, 1.32–1.37; p < 0.0001). Aside from vasodilator therapy, the risk of recurrent hyperkalemia was not increased with concomitant medication. In this cohort study, liver disease was an independent risk factor strongly associated with recurrent hyperkalemia within 1 year, independent of concomitant renin–angiotensin–aldosterone system inhibitor or potassium-sparing diuretic use. MDPI 2023-07-08 /pmc/articles/PMC10380673/ /pubmed/37510679 http://dx.doi.org/10.3390/jcm12144562 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahdoot, Rebecca S.
Hsiung, Jui-Ting
Agiro, Abiy
Brahmbhatt, Yasmin G.
Cooper, Kerry
Fawaz, Souhiela
Westfall, Laura
Kalantar-Zadeh, Kamyar
Streja, Elani
Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title_full Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title_fullStr Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title_full_unstemmed Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title_short Liver Disease Is a Risk Factor for Recurrent Hyperkalemia: A Retrospective Cohort Study
title_sort liver disease is a risk factor for recurrent hyperkalemia: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380673/
https://www.ncbi.nlm.nih.gov/pubmed/37510679
http://dx.doi.org/10.3390/jcm12144562
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