Paclitaxel Delivery to the Brain for Glioblastoma Treatment

The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawle...

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Detalles Bibliográficos
Autores principales: AbdEl-haq, Muhammad, Kumar, Awanish, Ait Mohand, Fatima-ezzahra, Kravchenko-Balasha, Nataly, Rottenberg, Yakir, Domb, Abraham J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380674/
https://www.ncbi.nlm.nih.gov/pubmed/37511480
http://dx.doi.org/10.3390/ijms241411722
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author AbdEl-haq, Muhammad
Kumar, Awanish
Ait Mohand, Fatima-ezzahra
Kravchenko-Balasha, Nataly
Rottenberg, Yakir
Domb, Abraham J.
author_facet AbdEl-haq, Muhammad
Kumar, Awanish
Ait Mohand, Fatima-ezzahra
Kravchenko-Balasha, Nataly
Rottenberg, Yakir
Domb, Abraham J.
author_sort AbdEl-haq, Muhammad
collection PubMed
description The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel.
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spelling pubmed-103806742023-07-29 Paclitaxel Delivery to the Brain for Glioblastoma Treatment AbdEl-haq, Muhammad Kumar, Awanish Ait Mohand, Fatima-ezzahra Kravchenko-Balasha, Nataly Rottenberg, Yakir Domb, Abraham J. Int J Mol Sci Communication The development of paclitaxel-loaded polymeric nanoparticles for the treatment of brain tumors was investigated. Poly(lactide-glycolide) (PLGA) nanoparticles containing 10% w/w paclitaxel with a particle size of 216 nm were administered through intranasal and intravenous routes to male Sprague–Dawley rats at a dose of 5 mg/kg. Both routes of administration showed appreciable accumulation of paclitaxel in brain tissue, liver, and kidney without any sign of toxicity. The anti-proliferative effect of the nanoparticles on glioblastoma tumor cells was comparable to that of free paclitaxel. MDPI 2023-07-21 /pmc/articles/PMC10380674/ /pubmed/37511480 http://dx.doi.org/10.3390/ijms241411722 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
AbdEl-haq, Muhammad
Kumar, Awanish
Ait Mohand, Fatima-ezzahra
Kravchenko-Balasha, Nataly
Rottenberg, Yakir
Domb, Abraham J.
Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title_full Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title_fullStr Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title_full_unstemmed Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title_short Paclitaxel Delivery to the Brain for Glioblastoma Treatment
title_sort paclitaxel delivery to the brain for glioblastoma treatment
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380674/
https://www.ncbi.nlm.nih.gov/pubmed/37511480
http://dx.doi.org/10.3390/ijms241411722
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