Cargando…

GL-II-73, a Positive Allosteric Modulator of α5GABA(A) Receptors, Reverses Dopamine System Dysfunction Associated with Pilocarpine-Induced Temporal Lobe Epilepsy

Although seizures are a hallmark feature of temporal lobe epilepsy (TLE), psychiatric comorbidities, including psychosis, are frequently associated with TLE and contribute to decreased quality of life. Currently, there are no defined therapeutic protocols to manage psychosis in TLE patients, as anti...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCoy, Alexandra M., Prevot, Thomas D., Sharmin, Dishary, Cook, James M., Sibille, Etienne L., Lodge, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380722/ https://www.ncbi.nlm.nih.gov/pubmed/37511346 http://dx.doi.org/10.3390/ijms241411588

Ejemplares similares

Positive Allosteric Modulation of α5-GABA(A) Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle
por: McCoy, Alexandra M, et al.
Publicado: (2022)

Hippocampal α5-GABA(A) Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area
por: Perez, Stephanie M., et al.
Publicado: (2022)

Synthesis and Receptor Binding Studies of α5 GABA(A)R Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders
por: Sharmin, Dishary, et al.
Publicado: (2023)

The pilocarpine model of temporal lobe epilepsy
por: Curia, Giulia, et al.
Publicado: (2008)

Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy
por: Henkel, Nicholas D., et al.
Publicado: (2021)

Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy
por: Ahmed, Md. Mahiuddin, et al.
Publicado: (2021)

Therapeutic effects of KRM-II-81, positive allosteric modulator for α2/3 subunit containing GABA(A) receptors, in a mouse model of Dravet syndrome
por: Nakakubo, Sachiko, et al.
Publicado: (2023)

Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy
por: Müller, Julia, et al.
Publicado: (2020)

Antiepileptogenic Effects of Anakinra, Lamotrigine and Their Combination in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy in Rats
por: Zubareva, Olga E., et al.
Publicado: (2023)

Beneficial Effects of Probiotic Bifidobacterium longum in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy in Rats
por: Zubareva, Olga E., et al.
Publicado: (2023)

Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation
por: Fee, Corey, et al.
Publicado: (2021)

Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine–induced temporal lobe epilepsy model
por: Nagao, Yuki, et al.
Publicado: (2013)

Validation of Suitable Reference Genes for Expression Studies in Different Pilocarpine-Induced Models of Mesial Temporal Lobe Epilepsy
por: Marques, Thalita Ewellyn Batista Sales, et al.
Publicado: (2013)

FDG-PET and NeuN-GFAP Immunohistochemistry of Hippocampus at Different Phases of the Pilocarpine Model of Temporal Lobe Epilepsy
por: Zhang, Liang, et al.
Publicado: (2015)

Reorganization of supramammillary–hippocampal pathways in the rat pilocarpine model of temporal lobe epilepsy: evidence for axon terminal sprouting
por: Soussi, Rabia, et al.
Publicado: (2014)

PT605. Alterations of functional connectivity in pilocarpine-induced mouse model of temporal lobe epilepsy in latent period
por: Lee, Hyoin, et al.
Publicado: (2016)

TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice
por: Wang, Zhouqing, et al.
Publicado: (2019)

Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy
por: Janković, Slobodan M, et al.
Publicado: (2021)

Progress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy—an X-ray fluorescence microscopy study
por: Chwiej, J., et al.
Publicado: (2012)

Changes in Metabotropic Glutamate Receptor Gene Expression in Rat Brain in a Lithium–Pilocarpine Model of Temporal Lobe Epilepsy
por: Kovalenko, Anna A., et al.
Publicado: (2022)

Influence of Aspirin on Pilocarpine-Induced Epilepsy in Mice
por: Jeong, Kyoung Hoon, et al.
Publicado: (2013)

Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
por: Schipper, S., et al.
Publicado: (2015)

Identification of Endogenous Reference Genes for the Analysis of microRNA Expression in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy
por: de Araújo, Mykaella Andrade, et al.
Publicado: (2014)

Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy
por: Santos, Evelin Antonieli da Silva, et al.
Publicado: (2015)

Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy
por: Kourdougli, Nazim, et al.
Publicado: (2015)

Author Correction: TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice
por: Wang, Zhouqing, et al.
Publicado: (2019)

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator
por: Piantadosi, Sean C., et al.
Publicado: (2016)

Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy
por: Dong, Yuan-Yuan, et al.
Publicado: (2020)

The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/β-Catenin Signaling Pathway
por: Cui, Hongxia, et al.
Publicado: (2022)

Impairments of Long-Term Synaptic Plasticity in the Hippocampus of Young Rats during the Latent Phase of the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy
por: Postnikova, Tatyana Y., et al.
Publicado: (2021)

GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats
por: Kosmowska, Barbara, et al.
Publicado: (2023)

Retracted: The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/β-Catenin Signaling Pathway
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Antiepileptogenic and Neuroprotective Effects of Pergularia daemia on Pilocarpine Model of Epilepsy
por: Kandeda, Antoine K., et al.
Publicado: (2017)

Aberrant Dopamine System Function in the Ferrous Amyloid Buthionine (FAB) Rat Model of Alzheimer’s Disease
por: Perez, Stephanie M., et al.
Publicado: (2023)

Allosteric Modulation of αβδ GABA(A) Receptors
por: Feng, Hua-Jun
Publicado: (2010)

Changes in the sensitivity of GABA(A) current rundown to drug treatments in a model of temporal lobe epilepsy
por: Cifelli, Pierangelo, et al.
Publicado: (2013)

Increased expression of GABA(A) receptor subunits associated with tonic inhibition in patients with temporal lobe epilepsy
por: Sperk, Günther, et al.
Publicado: (2021)

Αlpha 5 subunit-containing GABA(A) receptors in temporal lobe epilepsy with normal MRI
por: McGinnity, Colm J, et al.
Publicado: (2021)

Pilocarpine
por: Griffiths, H. T.
Publicado: (1882)

α5-GABAA Receptor Modulation Reverses Behavioral and Neurophysiological Correlates of Psychosis in Rats with Ventral Hippocampal Alzheimer’s Disease-like Pathology
por: Eassa, Nicole E., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tgeam9385sg1scdcnank6vfpd4