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Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers
Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human cancers remains unclear. In this study, through comprehensive analysis of data from The Cancer Genome Atlas (TCGA) datasets, we found that S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380780/ https://www.ncbi.nlm.nih.gov/pubmed/37511325 http://dx.doi.org/10.3390/ijms241411566 |
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author | Kuai, Xingwang Lv, Jiaying Zhang, Junyu Xu, Manyu Ji, Juling |
author_facet | Kuai, Xingwang Lv, Jiaying Zhang, Junyu Xu, Manyu Ji, Juling |
author_sort | Kuai, Xingwang |
collection | PubMed |
description | Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human cancers remains unclear. In this study, through comprehensive analysis of data from The Cancer Genome Atlas (TCGA) datasets, we found that SERPINA1 was dysregulated in many cancers compared with normal tissues. SERPINA1 expression was significantly associated with prognosis, immune subtype, molecular subtype, immune checkpoint (ICP) genes, tumor mutational burden (TMB), microsatellite instability (MSI), and the estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) score. There was a strong connection between SERPINA1 expression and tumor-infiltrating lymphocytes, and SERPINA1 showed significant relation to gene markers of immune cells in digestive tumors. Fluorescence-based multiplex immunohistochemistry confirmed that SERPINA1 protein expression was related to clinicopathologic features and immune infiltrates in hepatic cancer. This study suggests that SERPINA can potentially serve as a novel biomarker for cancer prognosis and immunotherapy. |
format | Online Article Text |
id | pubmed-10380780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103807802023-07-29 Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers Kuai, Xingwang Lv, Jiaying Zhang, Junyu Xu, Manyu Ji, Juling Int J Mol Sci Article Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human cancers remains unclear. In this study, through comprehensive analysis of data from The Cancer Genome Atlas (TCGA) datasets, we found that SERPINA1 was dysregulated in many cancers compared with normal tissues. SERPINA1 expression was significantly associated with prognosis, immune subtype, molecular subtype, immune checkpoint (ICP) genes, tumor mutational burden (TMB), microsatellite instability (MSI), and the estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) score. There was a strong connection between SERPINA1 expression and tumor-infiltrating lymphocytes, and SERPINA1 showed significant relation to gene markers of immune cells in digestive tumors. Fluorescence-based multiplex immunohistochemistry confirmed that SERPINA1 protein expression was related to clinicopathologic features and immune infiltrates in hepatic cancer. This study suggests that SERPINA can potentially serve as a novel biomarker for cancer prognosis and immunotherapy. MDPI 2023-07-17 /pmc/articles/PMC10380780/ /pubmed/37511325 http://dx.doi.org/10.3390/ijms241411566 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuai, Xingwang Lv, Jiaying Zhang, Junyu Xu, Manyu Ji, Juling Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title | Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title_full | Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title_fullStr | Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title_full_unstemmed | Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title_short | Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers |
title_sort | serpin family a member 1 is prognostic and involved in immunological regulation in human cancers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380780/ https://www.ncbi.nlm.nih.gov/pubmed/37511325 http://dx.doi.org/10.3390/ijms241411566 |
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