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Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease

Dickkopf 3 (Dkk3) is a WNT/β-catenin signaling pathway regulator secreted by tubular epithelial cells upon the influence of different stressors. Recently Dkk3 was described as a biomarker of tubular cell injury and a tool that may estimate the risk of chronic kidney disease (CKD) progression. The da...

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Autores principales: Dziamałek-Macioszczyk, Paulina, Winiarska, Agata, Pawłowska, Anna, Wojtacha, Paweł, Stompór, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380869/
https://www.ncbi.nlm.nih.gov/pubmed/37510820
http://dx.doi.org/10.3390/jcm12144705
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author Dziamałek-Macioszczyk, Paulina
Winiarska, Agata
Pawłowska, Anna
Wojtacha, Paweł
Stompór, Tomasz
author_facet Dziamałek-Macioszczyk, Paulina
Winiarska, Agata
Pawłowska, Anna
Wojtacha, Paweł
Stompór, Tomasz
author_sort Dziamałek-Macioszczyk, Paulina
collection PubMed
description Dickkopf 3 (Dkk3) is a WNT/β-catenin signaling pathway regulator secreted by tubular epithelial cells upon the influence of different stressors. Recently Dkk3 was described as a biomarker of tubular cell injury and a tool that may estimate the risk of chronic kidney disease (CKD) progression. The data about Dkk3 concentrations at particular stages of CKD are lacking. The aim of this study was to measure serum and urine Dkk3 levels in patients with different ‘renal status’ and evaluate its role as a biomarker of renal damage. One hundred individuals, aged between 24 and 85 years (mean 53.1 ± 17.1), were enrolled in the study. Five groups of 20 subjects each were recruited based on their kidney function. Serum and urine Dkk3 levels were measured by ELISA. The highest median urinary Dkk3 normalized to urinary creatinine was found in patients with established CKD (7051 pg/mg). It was two times higher in renal transplant patients (5705 pg/mg) than in healthy individuals (2654 pg/mg) and the glomerulonephritis group (2470 pg/mg). Urinary Dkk3 was associated with serum creatinine in participants with established CKD and following transplantation. Our results confirm the potential role of Dkk3 as a biomarker of an ongoing renal injury.
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spelling pubmed-103808692023-07-29 Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease Dziamałek-Macioszczyk, Paulina Winiarska, Agata Pawłowska, Anna Wojtacha, Paweł Stompór, Tomasz J Clin Med Article Dickkopf 3 (Dkk3) is a WNT/β-catenin signaling pathway regulator secreted by tubular epithelial cells upon the influence of different stressors. Recently Dkk3 was described as a biomarker of tubular cell injury and a tool that may estimate the risk of chronic kidney disease (CKD) progression. The data about Dkk3 concentrations at particular stages of CKD are lacking. The aim of this study was to measure serum and urine Dkk3 levels in patients with different ‘renal status’ and evaluate its role as a biomarker of renal damage. One hundred individuals, aged between 24 and 85 years (mean 53.1 ± 17.1), were enrolled in the study. Five groups of 20 subjects each were recruited based on their kidney function. Serum and urine Dkk3 levels were measured by ELISA. The highest median urinary Dkk3 normalized to urinary creatinine was found in patients with established CKD (7051 pg/mg). It was two times higher in renal transplant patients (5705 pg/mg) than in healthy individuals (2654 pg/mg) and the glomerulonephritis group (2470 pg/mg). Urinary Dkk3 was associated with serum creatinine in participants with established CKD and following transplantation. Our results confirm the potential role of Dkk3 as a biomarker of an ongoing renal injury. MDPI 2023-07-15 /pmc/articles/PMC10380869/ /pubmed/37510820 http://dx.doi.org/10.3390/jcm12144705 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dziamałek-Macioszczyk, Paulina
Winiarska, Agata
Pawłowska, Anna
Wojtacha, Paweł
Stompór, Tomasz
Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title_full Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title_fullStr Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title_full_unstemmed Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title_short Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease
title_sort patterns of dickkopf-3 serum and urine levels at different stages of chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380869/
https://www.ncbi.nlm.nih.gov/pubmed/37510820
http://dx.doi.org/10.3390/jcm12144705
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