Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development

The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been...

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Autores principales: Furukawa, Tatsuhiko, Mimami, Kentaro, Nagata, Toshiyuki, Yamamoto, Masatasu, Sato, Masami, Tanimoto, Akihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380948/
https://www.ncbi.nlm.nih.gov/pubmed/37511489
http://dx.doi.org/10.3390/ijms241411731
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author Furukawa, Tatsuhiko
Mimami, Kentaro
Nagata, Toshiyuki
Yamamoto, Masatasu
Sato, Masami
Tanimoto, Akihide
author_facet Furukawa, Tatsuhiko
Mimami, Kentaro
Nagata, Toshiyuki
Yamamoto, Masatasu
Sato, Masami
Tanimoto, Akihide
author_sort Furukawa, Tatsuhiko
collection PubMed
description The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples. We summarize some of these studies, detail several problems, and consider possible reasons for contradictory results and the needs for further research.
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spelling pubmed-103809482023-07-29 Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development Furukawa, Tatsuhiko Mimami, Kentaro Nagata, Toshiyuki Yamamoto, Masatasu Sato, Masami Tanimoto, Akihide Int J Mol Sci Review The circadian rhythm-related genes BHLHE40/DEC1 and BHLHE41/DEC2 have various functions under different cell and tissue conditions. BHLHE41/DEC2 has been reported to be both a cancer-suppressive and an oncogenic gene during cancer development. The effects of BHLHE41/DEC2 on differentiation have been examined using Bhlhe41/Dec2 knockout mice and/or in vitro differentiation models, and research has been conducted using genetic analysis of tumor cells, in vitro analysis of cancer cell lines, and immunohistochemical studies of the clinical samples. We summarize some of these studies, detail several problems, and consider possible reasons for contradictory results and the needs for further research. MDPI 2023-07-21 /pmc/articles/PMC10380948/ /pubmed/37511489 http://dx.doi.org/10.3390/ijms241411731 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Furukawa, Tatsuhiko
Mimami, Kentaro
Nagata, Toshiyuki
Yamamoto, Masatasu
Sato, Masami
Tanimoto, Akihide
Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title_full Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title_fullStr Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title_full_unstemmed Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title_short Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development
title_sort approach to functions of bhlhe41/dec2 in non-small lung cancer development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380948/
https://www.ncbi.nlm.nih.gov/pubmed/37511489
http://dx.doi.org/10.3390/ijms241411731
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AT nagatatoshiyuki approachtofunctionsofbhlhe41dec2innonsmalllungcancerdevelopment
AT yamamotomasatasu approachtofunctionsofbhlhe41dec2innonsmalllungcancerdevelopment
AT satomasami approachtofunctionsofbhlhe41dec2innonsmalllungcancerdevelopment
AT tanimotoakihide approachtofunctionsofbhlhe41dec2innonsmalllungcancerdevelopment

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