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Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach

The clinical presentation of Parkinson’s disease (PD) is often dominated by depressive symptoms, which can significantly impact the patients’ quality of life (QoL). However, it is not clear how these depressive symptoms are interconnected, or if some symptoms are more influential in affecting QoL. I...

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Autores principales: Heimrich, Konstantin G., Mendorf, Sarah, Schönenberg, Aline, Santos-García, Diego, Mir, Pablo, COPPADIS Study Group, Prell, Tino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380984/
https://www.ncbi.nlm.nih.gov/pubmed/37510732
http://dx.doi.org/10.3390/jcm12144616
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author Heimrich, Konstantin G.
Mendorf, Sarah
Schönenberg, Aline
Santos-García, Diego
Mir, Pablo
COPPADIS Study Group
Prell, Tino
author_facet Heimrich, Konstantin G.
Mendorf, Sarah
Schönenberg, Aline
Santos-García, Diego
Mir, Pablo
COPPADIS Study Group
Prell, Tino
author_sort Heimrich, Konstantin G.
collection PubMed
description The clinical presentation of Parkinson’s disease (PD) is often dominated by depressive symptoms, which can significantly impact the patients’ quality of life (QoL). However, it is not clear how these depressive symptoms are interconnected, or if some symptoms are more influential in affecting QoL. In the Cohort of Patients with Parkinson’s Disease in Spain (COPPADIS) study, 686 patients with PD were analyzed using network analyses. The patients completed the Beck Depression Inventory II (BDI-II) and provided their overall QoL (EUROHIS-QOL) at the beginning of the study. The study used centrality measures such as Expected Influence and Bridge Expected Influence to identify depressive symptoms that had the greatest impact on overall QoL. The results of exploratory network analyses indicate that the BDI-II items related to loss of energy, past failure, and tiredness or fatigue have the greatest impact on overall QoL as measured by the EUROHIS-QOL 8-item index. The loss of energy and tiredness or fatigue BDI-II items are also strongly associated with a number of different EUROHIS-QOL items, according to Bridge Expected Influences. For individuals suffering from PD, network analysis can aid in identifying significant non-motor symptoms that impact their QoL, thus paving the way for potential improvements.
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spelling pubmed-103809842023-07-29 Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach Heimrich, Konstantin G. Mendorf, Sarah Schönenberg, Aline Santos-García, Diego Mir, Pablo COPPADIS Study Group Prell, Tino J Clin Med Article The clinical presentation of Parkinson’s disease (PD) is often dominated by depressive symptoms, which can significantly impact the patients’ quality of life (QoL). However, it is not clear how these depressive symptoms are interconnected, or if some symptoms are more influential in affecting QoL. In the Cohort of Patients with Parkinson’s Disease in Spain (COPPADIS) study, 686 patients with PD were analyzed using network analyses. The patients completed the Beck Depression Inventory II (BDI-II) and provided their overall QoL (EUROHIS-QOL) at the beginning of the study. The study used centrality measures such as Expected Influence and Bridge Expected Influence to identify depressive symptoms that had the greatest impact on overall QoL. The results of exploratory network analyses indicate that the BDI-II items related to loss of energy, past failure, and tiredness or fatigue have the greatest impact on overall QoL as measured by the EUROHIS-QOL 8-item index. The loss of energy and tiredness or fatigue BDI-II items are also strongly associated with a number of different EUROHIS-QOL items, according to Bridge Expected Influences. For individuals suffering from PD, network analysis can aid in identifying significant non-motor symptoms that impact their QoL, thus paving the way for potential improvements. MDPI 2023-07-11 /pmc/articles/PMC10380984/ /pubmed/37510732 http://dx.doi.org/10.3390/jcm12144616 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Heimrich, Konstantin G.
Mendorf, Sarah
Schönenberg, Aline
Santos-García, Diego
Mir, Pablo
COPPADIS Study Group
Prell, Tino
Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title_full Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title_fullStr Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title_full_unstemmed Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title_short Depressive Symptoms and Their Impact on Quality of Life in Parkinson’s Disease: An Exploratory Network Analysis Approach
title_sort depressive symptoms and their impact on quality of life in parkinson’s disease: an exploratory network analysis approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380984/
https://www.ncbi.nlm.nih.gov/pubmed/37510732
http://dx.doi.org/10.3390/jcm12144616
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