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Chromosome Y Haplogroup R Was Associated with the Risk of Premature Myocardial Infarction with ST-Elevation: Data from the CholeSTEMI Registry

Cardiovascular disease (CVD) is the leading cause of death worldwide, with coronary artery disease (CAD) being one of its main manifestations. Both environmental and genetic factors are widely known to be related to CAD, such as smoking, diabetes mellitus, dyslipidemia, and a family history of CAD....

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Detalles Bibliográficos
Autores principales: Lorca, Rebeca, Aparicio, Andrea, Salgado, María, Álvarez-Velasco, Rut, Pascual, Isaac, Gomez, Juan, Vazquez-Coto, Daniel, Garcia-Lago, Claudia, Velázquez-Cuervo, Lucinda, Cuesta-Llavona, Elías, Avanzas, Pablo, Coto, Eliecer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381015/
https://www.ncbi.nlm.nih.gov/pubmed/37510926
http://dx.doi.org/10.3390/jcm12144812
Descripción
Sumario:Cardiovascular disease (CVD) is the leading cause of death worldwide, with coronary artery disease (CAD) being one of its main manifestations. Both environmental and genetic factors are widely known to be related to CAD, such as smoking, diabetes mellitus, dyslipidemia, and a family history of CAD. However, there is still a lack of information about other risk factors, especially those related to genetic mutations. Sex represents a classic CAD risk factor, as men are more likely to suffer CAD, but there is lack of evidence with regard to sex-specific genetic factors. We evaluated the Y chromosome haplogroups in a cohort of young Spanish male patients who suffered from STEMI. In this cohort, haplogroup R was significantly more frequent in STEMI patients.