Cargando…

Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2

BACKGROUND: Cancer relapse is associated with the presence of cancer stem-like cells (CSCs), which lead to multidirectional differentiation and unrestricted proliferative replication. Fumagillin, a myocotoxin produced by the saprophytic filamentous fungus Aspergillus fumigatus, has been reported to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Ke, Hu, Jian, Zhao, Ziyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381083/ https://www.ncbi.nlm.nih.gov/pubmed/37506053 http://dx.doi.org/10.1371/journal.pone.0289024

Ejemplares similares

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state
por: Frottin, Frédéric, et al.
Publicado: (2016)

Comprehensive comparison of MetAP2 tissue and cellular expression pattern in lean and obese rodents
por: Han, Jing, et al.
Publicado: (2018)

A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells
por: Siddik, Md Abu Bakkar, et al.
Publicado: (2019)

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
por: Wild, Klemens, et al.
Publicado: (2020)

Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors
por: Irfan, Iram, et al.
Publicado: (2022)

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs
por: Węglarz-Tomczak, Ewelina, et al.
Publicado: (2018)

Longevity-Extending MetAP2 Inhibitors Induce Caloric Restriction Through P53-Dependent Induction of GDF-15
por: MacArthur, Michael, et al.
Publicado: (2020)

Enterocytozoon bieneusi Microsporidiosis in Stem Cell Transplant Recipients Treated with Fumagillin
por: Bukreyeva, Iryna, et al.
Publicado: (2017)

Single and multiple dose evaluation of a novel MetAP2 inhibitor: Results of a randomized, double‐blind, placebo‐controlled clinical trial
por: Malloy, Jaret, et al.
Publicado: (2018)

Nosema ceranae Escapes Fumagillin Control in Honey Bees
por: Huang, Wei-Fone, et al.
Publicado: (2013)

Aspergillus fumigatus Fumagillin Contributes to Host Cell Damage
por: Guruceaga, Xabier, et al.
Publicado: (2021)

Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation
por: Xiao, Chong, et al.
Publicado: (2020)

Fumagillin Prodrug Nanotherapy Suppresses Macrophage Inflammatory Response via Endothelial Nitric Oxide
por: Zhou, Hui-fang, et al.
Publicado: (2014)

CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2
por: He, Wei-Peng, et al.
Publicado: (2020)

Computational validation of 3-ammonio-3-(4-oxido- 1H-imidazol-1-ium-5-yl) propane-1, 1-bis (olate) as a potent anti-tubercular drug against mt-MetAP
por: Chowdhury, Abhishek, et al.
Publicado: (2012)

Effects of Mycotoxin Fumagillin, Mevastatin, Radicicol, and Wortmannin on Photosynthesis of Chlamydomonas reinhardtii
por: Shi, Jiale, et al.
Publicado: (2023)

metaP-Server: A Web-Based Metabolomics Data Analysis Tool
por: Kastenmüller, Gabi, et al.
Publicado: (2011)

METAP1 Mutation Is a Novel Candidate for Autosomal Recessive Intellectual Disability
por: Caglayan, Ahmet Okay, et al.
Publicado: (2020)

LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells
por: Zhao, Ziyi, et al.
Publicado: (2023)

Successful Treatment of Disseminated Anncaliia algerae Microsporidial Infection With Combination Fumagillin and Albendazole
por: Boileau, Mélissa, et al.
Publicado: (2016)

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and Applications
por: Guruceaga, Xabier, et al.
Publicado: (2019)

Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET
por: Luo, Hao, et al.
Publicado: (2018)

A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus
por: Guruceaga, Xabier, et al.
Publicado: (2018)

Potential of Fumagillin and Agaricus blazei Mushroom Extract to Reduce Nosema ceranae in Honey Bees
por: Glavinic, Uros, et al.
Publicado: (2021)

Activation of c-MET Induces a Stem-Like Phenotype in Human Prostate Cancer
por: van Leenders, Geert J. L. H., et al.
Publicado: (2011)

The Fumagillin Gene Cluster, an Example of Hundreds of Genes under veA Control in Aspergillus fumigatus
por: Dhingra, Sourabh, et al.
Publicado: (2013)

Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury
por: Wen, Zhi-Hong, et al.
Publicado: (2021)

Cigarette smoking promotes keratinocyte malignancy via generation of cancer stem-like cells
por: Lin, Shuchun, et al.
Publicado: (2021)

Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats
por: Kass, Daniel J., et al.
Publicado: (2012)

Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway
por: Lin, Hsiao-Ching, et al.
Publicado: (2014)

In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combination
por: Gayathri, Loganathan, et al.
Publicado: (2020)

Cancer Stem Cell-Like Cells Derived from Malignant Peripheral Nerve Sheath Tumors
por: Spyra, Melanie, et al.
Publicado: (2011)

Adipose-derived mesenchymal stem cells (ASCs) may favour breast cancer recurrence via HGF/c-Met signaling
por: Eterno, Vincenzo, et al.
Publicado: (2013)

MET inhibition overcomes radiation resistance of glioblastoma stem‐like cells
por: De Bacco, Francesca, et al.
Publicado: (2016)

Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2
por: Watanabe, Natsuki, et al.
Publicado: (2023)

Chelerythrine Inhibits Stemness of Cancer Stem-Like Cells of Osteosarcoma and PI3K/AKT/mTOR Signal
por: Chen, Zhixing, et al.
Publicado: (2022)

Adipose-Derived Stem Cells Promote Proliferation and Invasion in Cervical Cancer by Targeting the HGF/c-MET Pathway
por: Zhai, Yongning, et al.
Publicado: (2020)

Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
por: Han, Tao, et al.
Publicado: (2023)

IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis
por: Chu, Pei-Yi, et al.
Publicado: (2022)

A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling
por: Yang, Fan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rhtt96i4hrghrlg3cl973j2uhh