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Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients

Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a mat...

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Autores principales: Bez, Patrick, D’ippolito, Giancarlo, Deiana, Carla Maria, Finco Gambier, Renato, Pica, Andrea, Costanzo, Giulia, Garzi, Giulia, Scarpa, Riccardo, Landini, Nicholas, Cinetto, Francesco, Firinu, Davide, Milito, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381188/
https://www.ncbi.nlm.nih.gov/pubmed/37511905
http://dx.doi.org/10.3390/life13071530
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author Bez, Patrick
D’ippolito, Giancarlo
Deiana, Carla Maria
Finco Gambier, Renato
Pica, Andrea
Costanzo, Giulia
Garzi, Giulia
Scarpa, Riccardo
Landini, Nicholas
Cinetto, Francesco
Firinu, Davide
Milito, Cinzia
author_facet Bez, Patrick
D’ippolito, Giancarlo
Deiana, Carla Maria
Finco Gambier, Renato
Pica, Andrea
Costanzo, Giulia
Garzi, Giulia
Scarpa, Riccardo
Landini, Nicholas
Cinetto, Francesco
Firinu, Davide
Milito, Cinzia
author_sort Bez, Patrick
collection PubMed
description Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response.
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spelling pubmed-103811882023-07-29 Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients Bez, Patrick D’ippolito, Giancarlo Deiana, Carla Maria Finco Gambier, Renato Pica, Andrea Costanzo, Giulia Garzi, Giulia Scarpa, Riccardo Landini, Nicholas Cinetto, Francesco Firinu, Davide Milito, Cinzia Life (Basel) Article Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. MDPI 2023-07-08 /pmc/articles/PMC10381188/ /pubmed/37511905 http://dx.doi.org/10.3390/life13071530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bez, Patrick
D’ippolito, Giancarlo
Deiana, Carla Maria
Finco Gambier, Renato
Pica, Andrea
Costanzo, Giulia
Garzi, Giulia
Scarpa, Riccardo
Landini, Nicholas
Cinetto, Francesco
Firinu, Davide
Milito, Cinzia
Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title_full Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title_fullStr Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title_full_unstemmed Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title_short Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
title_sort struggling with covid-19 in adult inborn errors of immunity patients: a case series of combination therapy and multiple lines of therapy for selected patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381188/
https://www.ncbi.nlm.nih.gov/pubmed/37511905
http://dx.doi.org/10.3390/life13071530
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