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Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a mat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381188/ https://www.ncbi.nlm.nih.gov/pubmed/37511905 http://dx.doi.org/10.3390/life13071530 |
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author | Bez, Patrick D’ippolito, Giancarlo Deiana, Carla Maria Finco Gambier, Renato Pica, Andrea Costanzo, Giulia Garzi, Giulia Scarpa, Riccardo Landini, Nicholas Cinetto, Francesco Firinu, Davide Milito, Cinzia |
author_facet | Bez, Patrick D’ippolito, Giancarlo Deiana, Carla Maria Finco Gambier, Renato Pica, Andrea Costanzo, Giulia Garzi, Giulia Scarpa, Riccardo Landini, Nicholas Cinetto, Francesco Firinu, Davide Milito, Cinzia |
author_sort | Bez, Patrick |
collection | PubMed |
description | Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. |
format | Online Article Text |
id | pubmed-10381188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103811882023-07-29 Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients Bez, Patrick D’ippolito, Giancarlo Deiana, Carla Maria Finco Gambier, Renato Pica, Andrea Costanzo, Giulia Garzi, Giulia Scarpa, Riccardo Landini, Nicholas Cinetto, Francesco Firinu, Davide Milito, Cinzia Life (Basel) Article Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. MDPI 2023-07-08 /pmc/articles/PMC10381188/ /pubmed/37511905 http://dx.doi.org/10.3390/life13071530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bez, Patrick D’ippolito, Giancarlo Deiana, Carla Maria Finco Gambier, Renato Pica, Andrea Costanzo, Giulia Garzi, Giulia Scarpa, Riccardo Landini, Nicholas Cinetto, Francesco Firinu, Davide Milito, Cinzia Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title | Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title_full | Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title_fullStr | Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title_full_unstemmed | Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title_short | Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients |
title_sort | struggling with covid-19 in adult inborn errors of immunity patients: a case series of combination therapy and multiple lines of therapy for selected patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381188/ https://www.ncbi.nlm.nih.gov/pubmed/37511905 http://dx.doi.org/10.3390/life13071530 |
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