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Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China

BACKGROUND/AIM: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. MATERIALS/METHODS: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospita...

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Autores principales: HUANG, Chunrong, WEI, Dong, LIU, Yahui, SHI, Guochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific and Technological Research Council of Turkey (TUBITAK) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381194/
https://www.ncbi.nlm.nih.gov/pubmed/36161612
http://dx.doi.org/10.3906/sag-2010-132
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author HUANG, Chunrong
WEI, Dong
LIU, Yahui
SHI, Guochao
author_facet HUANG, Chunrong
WEI, Dong
LIU, Yahui
SHI, Guochao
author_sort HUANG, Chunrong
collection PubMed
description BACKGROUND/AIM: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. MATERIALS/METHODS: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. The presence of adenovirus and other respiratory viruses was detected using polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. RESULTS: The top 3 most commonly occurring symptoms in Adv+ pneumonia patients were fever (66.7%), cough (63.3%), and tachypnea (16.7%). Patients with Adv+ pneumonia showed significantly higher rates of cough and fever and longer duration of hospitalization than patients with Adv+ non-pneumonia. In the Adv+ pneumonia group, consolidation (73.3%) was the most common imaging finding on chest CT scan, and the likelihood of involvement of bilateral lobes (60%) was high. Classical conspicuous consolidation with surrounding ground-glass opacity was observed in 5 (16.6%) patients with Adv+ pneumonia. Patients with Adv+ pneumonia showed a higher inhibition of T-cell immunity than did patients with Adv+ non-pneumonia, and counts of CD3(+), CD4(+), and CD8(+) T-cells may predict the presence of pneumonia in Adv+ patients. CONCLUSION: With regard to Adv+ pneumonia, the most frequent symptoms were cough and fever, and the most common CT pattern was consolidation; classical CT findings such as consolidation with surrounding ground-glass opacity could also be observed. Furthermore, our data indicated the incidence of abrogated cellular immunity in patients with Adv+ pneumonia.
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spelling pubmed-103811942023-07-29 Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China HUANG, Chunrong WEI, Dong LIU, Yahui SHI, Guochao Turk J Med Sci Research Article BACKGROUND/AIM: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. MATERIALS/METHODS: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. The presence of adenovirus and other respiratory viruses was detected using polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. RESULTS: The top 3 most commonly occurring symptoms in Adv+ pneumonia patients were fever (66.7%), cough (63.3%), and tachypnea (16.7%). Patients with Adv+ pneumonia showed significantly higher rates of cough and fever and longer duration of hospitalization than patients with Adv+ non-pneumonia. In the Adv+ pneumonia group, consolidation (73.3%) was the most common imaging finding on chest CT scan, and the likelihood of involvement of bilateral lobes (60%) was high. Classical conspicuous consolidation with surrounding ground-glass opacity was observed in 5 (16.6%) patients with Adv+ pneumonia. Patients with Adv+ pneumonia showed a higher inhibition of T-cell immunity than did patients with Adv+ non-pneumonia, and counts of CD3(+), CD4(+), and CD8(+) T-cells may predict the presence of pneumonia in Adv+ patients. CONCLUSION: With regard to Adv+ pneumonia, the most frequent symptoms were cough and fever, and the most common CT pattern was consolidation; classical CT findings such as consolidation with surrounding ground-glass opacity could also be observed. Furthermore, our data indicated the incidence of abrogated cellular immunity in patients with Adv+ pneumonia. Scientific and Technological Research Council of Turkey (TUBITAK) 2021-10-30 /pmc/articles/PMC10381194/ /pubmed/36161612 http://dx.doi.org/10.3906/sag-2010-132 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
HUANG, Chunrong
WEI, Dong
LIU, Yahui
SHI, Guochao
Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title_full Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title_fullStr Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title_full_unstemmed Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title_short Clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in Shanghai, China
title_sort clinical and imaging findings of patients diagnosed with adenovirus-positive pneumonia during 2015–2019 in shanghai, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381194/
https://www.ncbi.nlm.nih.gov/pubmed/36161612
http://dx.doi.org/10.3906/sag-2010-132
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