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Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy

Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer of multifactorial origin, characterized by histological and clinical manifestations. To date, there are no specific biomarkers or treatment modalities available to efficiently manage this neoplasia, demanding further resear...

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Autores principales: Plemmenos, Grigorios, Tzimogianni, Valentini, Fili, Christina, Piperi, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381251/
https://www.ncbi.nlm.nih.gov/pubmed/37511951
http://dx.doi.org/10.3390/life13071577
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author Plemmenos, Grigorios
Tzimogianni, Valentini
Fili, Christina
Piperi, Christina
author_facet Plemmenos, Grigorios
Tzimogianni, Valentini
Fili, Christina
Piperi, Christina
author_sort Plemmenos, Grigorios
collection PubMed
description Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer of multifactorial origin, characterized by histological and clinical manifestations. To date, there are no specific biomarkers or treatment modalities available to efficiently manage this neoplasia, demanding further research on the molecular background of OSCC pathology. Elucidation of signal transduction pathways and associated molecules with differential expression and function in OSCC are expected to enhance the future development of molecular targeted therapies. Among signaling proteins with a potential functional role in OSCC, the High Mobility Group Box 1 (HMGB1) protein has stimulated scientific interest due to frequent upregulation, and implication in the progression of many types of head and neck cancer types. HMGB1 is a nuclear nonhistone protein and an extracellularly secreted cytokine that can interact with several signaling molecules implicated in the pathogenic pathways of OSCC. Binding of HMGB1 to specific receptors on OSCC cells such as the receptor of AGE (RAGE) and the toll-like receptor (TLR) has been shown to initiate several intercellular signaling cascades that can promote OSCC growth, invasion, and metastasis, indicating a potential target for patient prognosis and therapeutic approaches. The purpose of this review is to explore the functional role and associated signaling of HMGB1 in OSCC in order to reveal potential therapeutic targeting options.
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spelling pubmed-103812512023-07-29 Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy Plemmenos, Grigorios Tzimogianni, Valentini Fili, Christina Piperi, Christina Life (Basel) Review Oral squamous cell carcinoma (OSCC) is the most frequent type of oral cancer of multifactorial origin, characterized by histological and clinical manifestations. To date, there are no specific biomarkers or treatment modalities available to efficiently manage this neoplasia, demanding further research on the molecular background of OSCC pathology. Elucidation of signal transduction pathways and associated molecules with differential expression and function in OSCC are expected to enhance the future development of molecular targeted therapies. Among signaling proteins with a potential functional role in OSCC, the High Mobility Group Box 1 (HMGB1) protein has stimulated scientific interest due to frequent upregulation, and implication in the progression of many types of head and neck cancer types. HMGB1 is a nuclear nonhistone protein and an extracellularly secreted cytokine that can interact with several signaling molecules implicated in the pathogenic pathways of OSCC. Binding of HMGB1 to specific receptors on OSCC cells such as the receptor of AGE (RAGE) and the toll-like receptor (TLR) has been shown to initiate several intercellular signaling cascades that can promote OSCC growth, invasion, and metastasis, indicating a potential target for patient prognosis and therapeutic approaches. The purpose of this review is to explore the functional role and associated signaling of HMGB1 in OSCC in order to reveal potential therapeutic targeting options. MDPI 2023-07-18 /pmc/articles/PMC10381251/ /pubmed/37511951 http://dx.doi.org/10.3390/life13071577 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Plemmenos, Grigorios
Tzimogianni, Valentini
Fili, Christina
Piperi, Christina
Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title_full Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title_fullStr Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title_full_unstemmed Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title_short Contributing Role of High Mobility Group Box 1 Signaling in Oral Cancer Development and Therapy
title_sort contributing role of high mobility group box 1 signaling in oral cancer development and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381251/
https://www.ncbi.nlm.nih.gov/pubmed/37511951
http://dx.doi.org/10.3390/life13071577
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