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Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration

Objective: A new diagnostic graphical tool—classification maps—supporting the detection of Age-Related Macular Degeneration (AMD) has been constructed. Methods: The classification maps are constructed using the ordinal regression model. In the ordinal regression model, the ordinal variable (the depe...

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Autores principales: Wąż, Piotr, Zorena, Katarzyna, Murawska, Anna, Bielińska-Wąż, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381320/
https://www.ncbi.nlm.nih.gov/pubmed/37511686
http://dx.doi.org/10.3390/jpm13071074
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author Wąż, Piotr
Zorena, Katarzyna
Murawska, Anna
Bielińska-Wąż, Dorota
author_facet Wąż, Piotr
Zorena, Katarzyna
Murawska, Anna
Bielińska-Wąż, Dorota
author_sort Wąż, Piotr
collection PubMed
description Objective: A new diagnostic graphical tool—classification maps—supporting the detection of Age-Related Macular Degeneration (AMD) has been constructed. Methods: The classification maps are constructed using the ordinal regression model. In the ordinal regression model, the ordinal variable (the dependent variable) is the degree of the advancement of AMD. The other variables, such as CRT (Central Retinal Thickness), GCC (Ganglion Cell Complex), MPOD (Macular Pigment Optical Density), ETDRS (Early Treatment Diabetic Retinopathy Study), Snellen and Age have also been used in the analysis and are represented on the axes of the maps. Results: Here, 132 eyes were examined and classified to the AMD advancement level according to the four-point Age-Related Eye Disease Scale (AREDS): AREDS 1, AREDS 2, AREDS 3 and AREDS 4. These data were used for the creation of two-dimensional classification maps for each of the four stages of AMD. Conclusions: The maps allow us to perform the classification of the patient’s eyes to particular stages of AMD. The pairs of the variables represented on the axes of the maps can be treated as diagnostic identifiers necessary for the classification to particular stages of AMD.
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spelling pubmed-103813202023-07-29 Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration Wąż, Piotr Zorena, Katarzyna Murawska, Anna Bielińska-Wąż, Dorota J Pers Med Article Objective: A new diagnostic graphical tool—classification maps—supporting the detection of Age-Related Macular Degeneration (AMD) has been constructed. Methods: The classification maps are constructed using the ordinal regression model. In the ordinal regression model, the ordinal variable (the dependent variable) is the degree of the advancement of AMD. The other variables, such as CRT (Central Retinal Thickness), GCC (Ganglion Cell Complex), MPOD (Macular Pigment Optical Density), ETDRS (Early Treatment Diabetic Retinopathy Study), Snellen and Age have also been used in the analysis and are represented on the axes of the maps. Results: Here, 132 eyes were examined and classified to the AMD advancement level according to the four-point Age-Related Eye Disease Scale (AREDS): AREDS 1, AREDS 2, AREDS 3 and AREDS 4. These data were used for the creation of two-dimensional classification maps for each of the four stages of AMD. Conclusions: The maps allow us to perform the classification of the patient’s eyes to particular stages of AMD. The pairs of the variables represented on the axes of the maps can be treated as diagnostic identifiers necessary for the classification to particular stages of AMD. MDPI 2023-06-29 /pmc/articles/PMC10381320/ /pubmed/37511686 http://dx.doi.org/10.3390/jpm13071074 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wąż, Piotr
Zorena, Katarzyna
Murawska, Anna
Bielińska-Wąż, Dorota
Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title_full Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title_fullStr Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title_full_unstemmed Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title_short Classification Maps: A New Mathematical Tool Supporting the Diagnosis of Age-Related Macular Degeneration
title_sort classification maps: a new mathematical tool supporting the diagnosis of age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381320/
https://www.ncbi.nlm.nih.gov/pubmed/37511686
http://dx.doi.org/10.3390/jpm13071074
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