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Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Coronary revascularization is one of the most studied treatment modalities in cardiology; however, there is no consensus among experts about its indications in patients with stable coronary artery disease (SCAD). Contemporary data regarding the role of revascularization in SCAD are in clear conflict...

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Autores principales: Bershtein, Leonid, Sumin, Alexey, Zbyshevskaya, Elizaveta, Gumerova, Victoria, Tsurtsumia, Darejan, Kochanov, Igor, Andreeva, Alina, Piltakian, Vartan, Sayganov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381336/
https://www.ncbi.nlm.nih.gov/pubmed/37511870
http://dx.doi.org/10.3390/life13071497
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author Bershtein, Leonid
Sumin, Alexey
Zbyshevskaya, Elizaveta
Gumerova, Victoria
Tsurtsumia, Darejan
Kochanov, Igor
Andreeva, Alina
Piltakian, Vartan
Sayganov, Sergey
author_facet Bershtein, Leonid
Sumin, Alexey
Zbyshevskaya, Elizaveta
Gumerova, Victoria
Tsurtsumia, Darejan
Kochanov, Igor
Andreeva, Alina
Piltakian, Vartan
Sayganov, Sergey
author_sort Bershtein, Leonid
collection PubMed
description Coronary revascularization is one of the most studied treatment modalities in cardiology; however, there is no consensus among experts about its indications in patients with stable coronary artery disease (SCAD). Contemporary data regarding the role of revascularization in SCAD are in clear conflict with the current European guidelines. This article discusses the main statements of the most significant American and European Guidelines on myocardial revascularization of the last decade and also analyzes the appropriateness of revascularization to improve the prognosis and symptoms in SCAD in the light of new research data, primarily the ISCHEMIA study (NCT01471522) and the ACC/AHA 2021 Revascularization Guidelines based on them. Data on the revascularization in SCAD obtained after the completion of ISCHEMIA (including the interim analysis of ISCHEMIA-EXTEND) and their potential significance are discussed. The results of ISCHEMIA sub-analyses in the most important “controversial” subgroups (3-vessel disease, proximal left anterior descending artery disease, strongly positive stress test, etc.) are reviewed, as are the results of the ISCHEMIA-CKD substudy in patients with severe chronic kidney disease (CKD).
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spelling pubmed-103813362023-07-29 Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis Bershtein, Leonid Sumin, Alexey Zbyshevskaya, Elizaveta Gumerova, Victoria Tsurtsumia, Darejan Kochanov, Igor Andreeva, Alina Piltakian, Vartan Sayganov, Sergey Life (Basel) Review Coronary revascularization is one of the most studied treatment modalities in cardiology; however, there is no consensus among experts about its indications in patients with stable coronary artery disease (SCAD). Contemporary data regarding the role of revascularization in SCAD are in clear conflict with the current European guidelines. This article discusses the main statements of the most significant American and European Guidelines on myocardial revascularization of the last decade and also analyzes the appropriateness of revascularization to improve the prognosis and symptoms in SCAD in the light of new research data, primarily the ISCHEMIA study (NCT01471522) and the ACC/AHA 2021 Revascularization Guidelines based on them. Data on the revascularization in SCAD obtained after the completion of ISCHEMIA (including the interim analysis of ISCHEMIA-EXTEND) and their potential significance are discussed. The results of ISCHEMIA sub-analyses in the most important “controversial” subgroups (3-vessel disease, proximal left anterior descending artery disease, strongly positive stress test, etc.) are reviewed, as are the results of the ISCHEMIA-CKD substudy in patients with severe chronic kidney disease (CKD). MDPI 2023-07-01 /pmc/articles/PMC10381336/ /pubmed/37511870 http://dx.doi.org/10.3390/life13071497 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bershtein, Leonid
Sumin, Alexey
Zbyshevskaya, Elizaveta
Gumerova, Victoria
Tsurtsumia, Darejan
Kochanov, Igor
Andreeva, Alina
Piltakian, Vartan
Sayganov, Sergey
Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title_full Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title_fullStr Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title_full_unstemmed Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title_short Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis
title_sort stable coronary artery disease: who finally benefits from coronary revascularization in the modern era? the ischemia and interim ischemia-extend analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381336/
https://www.ncbi.nlm.nih.gov/pubmed/37511870
http://dx.doi.org/10.3390/life13071497
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