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Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP

(1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation is not yet established in all inflammatory bowel disease (IBD) units. The aim of the study was to evaluate the impact of transition on IBD outcomes. (2) Methods: Multicentre, r...

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Autores principales: Rubín de Célix, Cristina, Martín-de-Carpi, Javier, Pujol-Muncunill, Gemma, Palomino, Laura María, Velasco Rodríguez-Belvís, Marta, Martín-Masot, Rafael, Navas-López, Víctor Manuel, Ricart, Elena, Casanova, María José, Rodríguez-Martínez, Alejandro, Leo-Carnerero, Eduardo, Alcaraz, Alba, Mañosa, Miriam, Hernández, Vicent, Cobelas Cobelas, María Consuelo, Sánchez, César, Menchén, Luis, Mesonero, Francisco, Barreiro-De Acosta, Manuel, Martinón-Torres, Nazareth, Tejido Sandoval, Coral, Rendo Vázquez, Alicia, Corsino, Pilar, Vicente, Raquel, Hernández-Camba, Alejandro, Alberto Alonso, José Ramón, Alonso-Abreu, I., Castro Millán, Ana María, Peries Reverter, Laia, Castro, Beatriz, Fernández-Salgado, Estela, Busto Cuiñas, M. Mercedes, Benítez, José Manuel, Madero, Lucía, Clemente, Fernando, Riestra, Sabino, Jiménez-Treviño, Santiago, Boscá-Watts, Maia, Crehuá-Gaudiza, Elena, Calvo Moya, Marta, Huguet, José María, Largo-Blanco, Ester-María, González Vives, Leticia, Plaza, Rocío, Guerra, Iván, Barrio, Josefa, Escartín, Laura, Alfambra, Erika, Cruz, Noelia, Muñoz, M. Carmen, Muñoz Pino, María Guadalupe, Van Domselaar, Manuel, Botella, Belén, Monfort Miquel, David, Rodríguez Grau, M. Carmen, De La Mano, Agustín, Ber, Yolanda, Calvo Iñiguez, María, Martínez-Pérez, Teresa de Jesús, Chaparro, María, Gisbert, Javier P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381381/
https://www.ncbi.nlm.nih.gov/pubmed/37510928
http://dx.doi.org/10.3390/jcm12144813
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author Rubín de Célix, Cristina
Martín-de-Carpi, Javier
Pujol-Muncunill, Gemma
Palomino, Laura María
Velasco Rodríguez-Belvís, Marta
Martín-Masot, Rafael
Navas-López, Víctor Manuel
Ricart, Elena
Casanova, María José
Rodríguez-Martínez, Alejandro
Leo-Carnerero, Eduardo
Alcaraz, Alba
Mañosa, Miriam
Hernández, Vicent
Cobelas Cobelas, María Consuelo
Sánchez, César
Menchén, Luis
Mesonero, Francisco
Barreiro-De Acosta, Manuel
Martinón-Torres, Nazareth
Tejido Sandoval, Coral
Rendo Vázquez, Alicia
Corsino, Pilar
Vicente, Raquel
Hernández-Camba, Alejandro
Alberto Alonso, José Ramón
Alonso-Abreu, I.
Castro Millán, Ana María
Peries Reverter, Laia
Castro, Beatriz
Fernández-Salgado, Estela
Busto Cuiñas, M. Mercedes
Benítez, José Manuel
Madero, Lucía
Clemente, Fernando
Riestra, Sabino
Jiménez-Treviño, Santiago
Boscá-Watts, Maia
Crehuá-Gaudiza, Elena
Calvo Moya, Marta
Huguet, José María
Largo-Blanco, Ester-María
González Vives, Leticia
Plaza, Rocío
Guerra, Iván
Barrio, Josefa
Escartín, Laura
Alfambra, Erika
Cruz, Noelia
Muñoz, M. Carmen
Muñoz Pino, María Guadalupe
Van Domselaar, Manuel
Botella, Belén
Monfort Miquel, David
Rodríguez Grau, M. Carmen
De La Mano, Agustín
Ber, Yolanda
Calvo Iñiguez, María
Martínez-Pérez, Teresa de Jesús
Chaparro, María
Gisbert, Javier P.
author_facet Rubín de Célix, Cristina
Martín-de-Carpi, Javier
Pujol-Muncunill, Gemma
Palomino, Laura María
Velasco Rodríguez-Belvís, Marta
Martín-Masot, Rafael
Navas-López, Víctor Manuel
Ricart, Elena
Casanova, María José
Rodríguez-Martínez, Alejandro
Leo-Carnerero, Eduardo
Alcaraz, Alba
Mañosa, Miriam
Hernández, Vicent
Cobelas Cobelas, María Consuelo
Sánchez, César
Menchén, Luis
Mesonero, Francisco
Barreiro-De Acosta, Manuel
Martinón-Torres, Nazareth
Tejido Sandoval, Coral
Rendo Vázquez, Alicia
Corsino, Pilar
Vicente, Raquel
Hernández-Camba, Alejandro
Alberto Alonso, José Ramón
Alonso-Abreu, I.
Castro Millán, Ana María
Peries Reverter, Laia
Castro, Beatriz
Fernández-Salgado, Estela
Busto Cuiñas, M. Mercedes
Benítez, José Manuel
Madero, Lucía
Clemente, Fernando
Riestra, Sabino
Jiménez-Treviño, Santiago
Boscá-Watts, Maia
Crehuá-Gaudiza, Elena
Calvo Moya, Marta
Huguet, José María
Largo-Blanco, Ester-María
González Vives, Leticia
Plaza, Rocío
Guerra, Iván
Barrio, Josefa
Escartín, Laura
Alfambra, Erika
Cruz, Noelia
Muñoz, M. Carmen
Muñoz Pino, María Guadalupe
Van Domselaar, Manuel
Botella, Belén
Monfort Miquel, David
Rodríguez Grau, M. Carmen
De La Mano, Agustín
Ber, Yolanda
Calvo Iñiguez, María
Martínez-Pérez, Teresa de Jesús
Chaparro, María
Gisbert, Javier P.
author_sort Rubín de Célix, Cristina
collection PubMed
description (1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation is not yet established in all inflammatory bowel disease (IBD) units. The aim of the study was to evaluate the impact of transition on IBD outcomes. (2) Methods: Multicentre, retrospective and observational study of IBD paediatric patients transferred to an adult IBD unit between 2017–2020. Two groups were compared: transition (≥1 joint visit involving the gastroenterologist, the paediatrician, a programme coordinator, the parents and the patient) and no-transition. Outcomes within one year after transfer were analysed. The main variable was poor clinical outcome (IBD flare, hospitalisation, surgery or any change in the treatment because of a flare). Predictive factors of poor clinical outcome were identified with multivariable analysis. (3) Results: A total of 278 patients from 34 Spanish hospitals were included. One hundred eighty-five patients (67%) from twenty-two hospitals (65%) performed a structured transition. Eighty-nine patients had poor clinical outcome at one year after transfer: 27% in the transition and 43% in the no-transition group (p = 0.005). One year after transfer, no-transition patients were more likely to have a flare (36% vs. 22%; p = 0.018) and reported more hospitalisations (10% vs. 3%; p = 0.025). The lack of transition, as well as parameters at transfer, including IBD activity, body mass index < 18.5 and corticosteroid treatment, were associated with poor clinical outcome. One patient in the transition group (0.4%) was lost to follow-up. (4) Conclusion: Transition care programmes improve patients’ outcomes after the transfer from paediatric to adult IBD units. Active IBD at transfer impairs outcomes.
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spelling pubmed-103813812023-07-29 Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP Rubín de Célix, Cristina Martín-de-Carpi, Javier Pujol-Muncunill, Gemma Palomino, Laura María Velasco Rodríguez-Belvís, Marta Martín-Masot, Rafael Navas-López, Víctor Manuel Ricart, Elena Casanova, María José Rodríguez-Martínez, Alejandro Leo-Carnerero, Eduardo Alcaraz, Alba Mañosa, Miriam Hernández, Vicent Cobelas Cobelas, María Consuelo Sánchez, César Menchén, Luis Mesonero, Francisco Barreiro-De Acosta, Manuel Martinón-Torres, Nazareth Tejido Sandoval, Coral Rendo Vázquez, Alicia Corsino, Pilar Vicente, Raquel Hernández-Camba, Alejandro Alberto Alonso, José Ramón Alonso-Abreu, I. Castro Millán, Ana María Peries Reverter, Laia Castro, Beatriz Fernández-Salgado, Estela Busto Cuiñas, M. Mercedes Benítez, José Manuel Madero, Lucía Clemente, Fernando Riestra, Sabino Jiménez-Treviño, Santiago Boscá-Watts, Maia Crehuá-Gaudiza, Elena Calvo Moya, Marta Huguet, José María Largo-Blanco, Ester-María González Vives, Leticia Plaza, Rocío Guerra, Iván Barrio, Josefa Escartín, Laura Alfambra, Erika Cruz, Noelia Muñoz, M. Carmen Muñoz Pino, María Guadalupe Van Domselaar, Manuel Botella, Belén Monfort Miquel, David Rodríguez Grau, M. Carmen De La Mano, Agustín Ber, Yolanda Calvo Iñiguez, María Martínez-Pérez, Teresa de Jesús Chaparro, María Gisbert, Javier P. J Clin Med Article (1) Background: Transition is a planned movement of paediatric patients to adult healthcare systems, and its implementation is not yet established in all inflammatory bowel disease (IBD) units. The aim of the study was to evaluate the impact of transition on IBD outcomes. (2) Methods: Multicentre, retrospective and observational study of IBD paediatric patients transferred to an adult IBD unit between 2017–2020. Two groups were compared: transition (≥1 joint visit involving the gastroenterologist, the paediatrician, a programme coordinator, the parents and the patient) and no-transition. Outcomes within one year after transfer were analysed. The main variable was poor clinical outcome (IBD flare, hospitalisation, surgery or any change in the treatment because of a flare). Predictive factors of poor clinical outcome were identified with multivariable analysis. (3) Results: A total of 278 patients from 34 Spanish hospitals were included. One hundred eighty-five patients (67%) from twenty-two hospitals (65%) performed a structured transition. Eighty-nine patients had poor clinical outcome at one year after transfer: 27% in the transition and 43% in the no-transition group (p = 0.005). One year after transfer, no-transition patients were more likely to have a flare (36% vs. 22%; p = 0.018) and reported more hospitalisations (10% vs. 3%; p = 0.025). The lack of transition, as well as parameters at transfer, including IBD activity, body mass index < 18.5 and corticosteroid treatment, were associated with poor clinical outcome. One patient in the transition group (0.4%) was lost to follow-up. (4) Conclusion: Transition care programmes improve patients’ outcomes after the transfer from paediatric to adult IBD units. Active IBD at transfer impairs outcomes. MDPI 2023-07-21 /pmc/articles/PMC10381381/ /pubmed/37510928 http://dx.doi.org/10.3390/jcm12144813 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rubín de Célix, Cristina
Martín-de-Carpi, Javier
Pujol-Muncunill, Gemma
Palomino, Laura María
Velasco Rodríguez-Belvís, Marta
Martín-Masot, Rafael
Navas-López, Víctor Manuel
Ricart, Elena
Casanova, María José
Rodríguez-Martínez, Alejandro
Leo-Carnerero, Eduardo
Alcaraz, Alba
Mañosa, Miriam
Hernández, Vicent
Cobelas Cobelas, María Consuelo
Sánchez, César
Menchén, Luis
Mesonero, Francisco
Barreiro-De Acosta, Manuel
Martinón-Torres, Nazareth
Tejido Sandoval, Coral
Rendo Vázquez, Alicia
Corsino, Pilar
Vicente, Raquel
Hernández-Camba, Alejandro
Alberto Alonso, José Ramón
Alonso-Abreu, I.
Castro Millán, Ana María
Peries Reverter, Laia
Castro, Beatriz
Fernández-Salgado, Estela
Busto Cuiñas, M. Mercedes
Benítez, José Manuel
Madero, Lucía
Clemente, Fernando
Riestra, Sabino
Jiménez-Treviño, Santiago
Boscá-Watts, Maia
Crehuá-Gaudiza, Elena
Calvo Moya, Marta
Huguet, José María
Largo-Blanco, Ester-María
González Vives, Leticia
Plaza, Rocío
Guerra, Iván
Barrio, Josefa
Escartín, Laura
Alfambra, Erika
Cruz, Noelia
Muñoz, M. Carmen
Muñoz Pino, María Guadalupe
Van Domselaar, Manuel
Botella, Belén
Monfort Miquel, David
Rodríguez Grau, M. Carmen
De La Mano, Agustín
Ber, Yolanda
Calvo Iñiguez, María
Martínez-Pérez, Teresa de Jesús
Chaparro, María
Gisbert, Javier P.
Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title_full Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title_fullStr Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title_full_unstemmed Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title_short Benefits of Paediatric to Adult Transition Programme in Inflammatory Bowel Disease: The BUTTERFLY Study of GETECCU and SEGHNP
title_sort benefits of paediatric to adult transition programme in inflammatory bowel disease: the butterfly study of geteccu and seghnp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381381/
https://www.ncbi.nlm.nih.gov/pubmed/37510928
http://dx.doi.org/10.3390/jcm12144813
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