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Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis

(1) Background: Hand-assisted laparoscopic surgery (HALS) has engendered growing attention as a safe procedure for the resection of metastatic liver disease. However, there is little data available regarding the outcomes of HALS for colorectal liver metastasis (CRLM) in patients over the age of 75....

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Autores principales: Mahamid, Ahmad, Abu-Zaydeh, Omar, Mattar, Samar, Kazlow, Esther, Froylich, Dvir, Sawaied, Muneer, Goldberg, Natalia, Berger, Yael, Sadot, Eran, Haddad, Riad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381412/
https://www.ncbi.nlm.nih.gov/pubmed/37510900
http://dx.doi.org/10.3390/jcm12144785
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author Mahamid, Ahmad
Abu-Zaydeh, Omar
Mattar, Samar
Kazlow, Esther
Froylich, Dvir
Sawaied, Muneer
Goldberg, Natalia
Berger, Yael
Sadot, Eran
Haddad, Riad
author_facet Mahamid, Ahmad
Abu-Zaydeh, Omar
Mattar, Samar
Kazlow, Esther
Froylich, Dvir
Sawaied, Muneer
Goldberg, Natalia
Berger, Yael
Sadot, Eran
Haddad, Riad
author_sort Mahamid, Ahmad
collection PubMed
description (1) Background: Hand-assisted laparoscopic surgery (HALS) has engendered growing attention as a safe procedure for the resection of metastatic liver disease. However, there is little data available regarding the outcomes of HALS for colorectal liver metastasis (CRLM) in patients over the age of 75. (2) Methods: We compare the short- and long-term outcomes of patients >75-years-old (defined in our study as “elderly patients” and referred to as group 1, G1), with patients <75-years-old (defined in our study as “younger patients” and referred to as group 2, G2). (3) Results: Of 145 patients, 28 were in G1 and 117 were in G2. The most common site of the primary tumor was the right colon in G1, and the left colon in G2 (p = 0.05). More patients in G1 underwent laparoscopic anterior segment resection compared with G2 (43% vs. 39% respectively) (p = 0.003). 53% of patients in G1 and 74% of patients in G2 completed neoadjuvant therapy (p = 0.04). The median size of the largest metastasis was 32 (IQR 19–52) mm in G1 and 20 (IQR 13–35) mm in G2 (p = 0.001). The rate of complications (Dindo-Clavien grade ≥ III) was slightly higher in G1 (p = 0.06). The overall 5-year survival was 30% in G1 and 52% in G2 (p = 0.12). (4) Conclusions: Hand-assisted laparoscopic surgery for colorectal liver metastasis is safe and effective in an elderly patient population.
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spelling pubmed-103814122023-07-29 Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis Mahamid, Ahmad Abu-Zaydeh, Omar Mattar, Samar Kazlow, Esther Froylich, Dvir Sawaied, Muneer Goldberg, Natalia Berger, Yael Sadot, Eran Haddad, Riad J Clin Med Article (1) Background: Hand-assisted laparoscopic surgery (HALS) has engendered growing attention as a safe procedure for the resection of metastatic liver disease. However, there is little data available regarding the outcomes of HALS for colorectal liver metastasis (CRLM) in patients over the age of 75. (2) Methods: We compare the short- and long-term outcomes of patients >75-years-old (defined in our study as “elderly patients” and referred to as group 1, G1), with patients <75-years-old (defined in our study as “younger patients” and referred to as group 2, G2). (3) Results: Of 145 patients, 28 were in G1 and 117 were in G2. The most common site of the primary tumor was the right colon in G1, and the left colon in G2 (p = 0.05). More patients in G1 underwent laparoscopic anterior segment resection compared with G2 (43% vs. 39% respectively) (p = 0.003). 53% of patients in G1 and 74% of patients in G2 completed neoadjuvant therapy (p = 0.04). The median size of the largest metastasis was 32 (IQR 19–52) mm in G1 and 20 (IQR 13–35) mm in G2 (p = 0.001). The rate of complications (Dindo-Clavien grade ≥ III) was slightly higher in G1 (p = 0.06). The overall 5-year survival was 30% in G1 and 52% in G2 (p = 0.12). (4) Conclusions: Hand-assisted laparoscopic surgery for colorectal liver metastasis is safe and effective in an elderly patient population. MDPI 2023-07-20 /pmc/articles/PMC10381412/ /pubmed/37510900 http://dx.doi.org/10.3390/jcm12144785 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahamid, Ahmad
Abu-Zaydeh, Omar
Mattar, Samar
Kazlow, Esther
Froylich, Dvir
Sawaied, Muneer
Goldberg, Natalia
Berger, Yael
Sadot, Eran
Haddad, Riad
Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title_full Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title_fullStr Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title_full_unstemmed Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title_short Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis
title_sort short- and long-term outcomes in elderly patients following hand-assisted laparoscopic surgery for colorectal liver metastasis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381412/
https://www.ncbi.nlm.nih.gov/pubmed/37510900
http://dx.doi.org/10.3390/jcm12144785
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