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Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review

Kidney graft failure is not a homogenous disease and the Banff classification distinguishes several types of graft rejection. The maintenance of a transplant and the treatment of its failure require specific medications and differ due to the underlying molecular mechanism. As a consequence, patients...

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Detalles Bibliográficos
Autores principales: Mizera, Jakub, Pilch, Justyna, Giordano, Ugo, Krajewska, Magdalena, Banasik, Mirosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381422/
https://www.ncbi.nlm.nih.gov/pubmed/37511833
http://dx.doi.org/10.3390/life13071458
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author Mizera, Jakub
Pilch, Justyna
Giordano, Ugo
Krajewska, Magdalena
Banasik, Mirosław
author_facet Mizera, Jakub
Pilch, Justyna
Giordano, Ugo
Krajewska, Magdalena
Banasik, Mirosław
author_sort Mizera, Jakub
collection PubMed
description Kidney graft failure is not a homogenous disease and the Banff classification distinguishes several types of graft rejection. The maintenance of a transplant and the treatment of its failure require specific medications and differ due to the underlying molecular mechanism. As a consequence, patients suffering from different rejection types will experience distinct side-effects upon therapy. The review is focused on comparing treatment regimens as well as presenting the latest insights into innovative therapeutic approaches in patients with an ongoing active ABMR, chronic active ABMR, chronic ABMR, acute TCMR, chronic active TCMR, borderline and mixed rejection. Furthermore, the profile of cardiovascular adverse effects in relation to the applied therapy was subjected to scrutiny. Lastly, a detailed assessment and comparison of different approaches were conducted in order to identify those that are the most and least detrimental for patients suffering from kidney graft failure.
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spelling pubmed-103814222023-07-29 Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review Mizera, Jakub Pilch, Justyna Giordano, Ugo Krajewska, Magdalena Banasik, Mirosław Life (Basel) Systematic Review Kidney graft failure is not a homogenous disease and the Banff classification distinguishes several types of graft rejection. The maintenance of a transplant and the treatment of its failure require specific medications and differ due to the underlying molecular mechanism. As a consequence, patients suffering from different rejection types will experience distinct side-effects upon therapy. The review is focused on comparing treatment regimens as well as presenting the latest insights into innovative therapeutic approaches in patients with an ongoing active ABMR, chronic active ABMR, chronic ABMR, acute TCMR, chronic active TCMR, borderline and mixed rejection. Furthermore, the profile of cardiovascular adverse effects in relation to the applied therapy was subjected to scrutiny. Lastly, a detailed assessment and comparison of different approaches were conducted in order to identify those that are the most and least detrimental for patients suffering from kidney graft failure. MDPI 2023-06-27 /pmc/articles/PMC10381422/ /pubmed/37511833 http://dx.doi.org/10.3390/life13071458 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Mizera, Jakub
Pilch, Justyna
Giordano, Ugo
Krajewska, Magdalena
Banasik, Mirosław
Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title_full Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title_fullStr Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title_full_unstemmed Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title_short Therapy in the Course of Kidney Graft Rejection—Implications for the Cardiovascular System—A Systematic Review
title_sort therapy in the course of kidney graft rejection—implications for the cardiovascular system—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381422/
https://www.ncbi.nlm.nih.gov/pubmed/37511833
http://dx.doi.org/10.3390/life13071458
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