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Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches
During the course of Crohn’s disease, the response of mesenteric adipose tissue to the production of inflammatory mediators and bacterial invasion through the intestinal mucosa results in the formation of creeping fat. Creeping fat describes the arresting finger-like projections that surround the in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381426/ https://www.ncbi.nlm.nih.gov/pubmed/37511642 http://dx.doi.org/10.3390/jpm13071029 |
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author | Aggeletopoulou, Ioanna Tsounis, Efthymios P. Mouzaki, Athanasia Triantos, Christos |
author_facet | Aggeletopoulou, Ioanna Tsounis, Efthymios P. Mouzaki, Athanasia Triantos, Christos |
author_sort | Aggeletopoulou, Ioanna |
collection | PubMed |
description | During the course of Crohn’s disease, the response of mesenteric adipose tissue to the production of inflammatory mediators and bacterial invasion through the intestinal mucosa results in the formation of creeping fat. Creeping fat describes the arresting finger-like projections that surround the inflamed bowel. In this review, the microscopic and macroscopic features of creeping fat and histological evidence for the importance of this tissue are discussed. Moreover, the most recent insights into the radiological assessment of creeping fat in patients with Crohn’s disease are reported. Advances in imaging techniques have revolutionized the possibility of visualization and quantification of adipose tissue depots with excellent accuracy. Visceral fat has been significantly correlated with various Crohn’s-disease-related outcomes. Despite the difficulties in distinguishing physiologic perienteric fat from creeping fat, the growing interest in fat-wrapping in Crohn’s disease has rejuvenated radiologic research. With regard to the noninvasive fat-wrapping assessment, a novel CT enterography-based mesenteric creeping fat index has been developed for the mitigation of the confounding effect of normal retroperitoneal and perienteric adipose tissue. Research on machine learning algorithms and computational radiomics in conjunction with mechanistic studies may be the key for the elucidation of the complex role of creeping fat in Crohn’s disease. |
format | Online Article Text |
id | pubmed-10381426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103814262023-07-29 Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches Aggeletopoulou, Ioanna Tsounis, Efthymios P. Mouzaki, Athanasia Triantos, Christos J Pers Med Review During the course of Crohn’s disease, the response of mesenteric adipose tissue to the production of inflammatory mediators and bacterial invasion through the intestinal mucosa results in the formation of creeping fat. Creeping fat describes the arresting finger-like projections that surround the inflamed bowel. In this review, the microscopic and macroscopic features of creeping fat and histological evidence for the importance of this tissue are discussed. Moreover, the most recent insights into the radiological assessment of creeping fat in patients with Crohn’s disease are reported. Advances in imaging techniques have revolutionized the possibility of visualization and quantification of adipose tissue depots with excellent accuracy. Visceral fat has been significantly correlated with various Crohn’s-disease-related outcomes. Despite the difficulties in distinguishing physiologic perienteric fat from creeping fat, the growing interest in fat-wrapping in Crohn’s disease has rejuvenated radiologic research. With regard to the noninvasive fat-wrapping assessment, a novel CT enterography-based mesenteric creeping fat index has been developed for the mitigation of the confounding effect of normal retroperitoneal and perienteric adipose tissue. Research on machine learning algorithms and computational radiomics in conjunction with mechanistic studies may be the key for the elucidation of the complex role of creeping fat in Crohn’s disease. MDPI 2023-06-21 /pmc/articles/PMC10381426/ /pubmed/37511642 http://dx.doi.org/10.3390/jpm13071029 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aggeletopoulou, Ioanna Tsounis, Efthymios P. Mouzaki, Athanasia Triantos, Christos Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title | Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title_full | Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title_fullStr | Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title_full_unstemmed | Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title_short | Creeping Fat in Crohn’s Disease—Surgical, Histological, and Radiological Approaches |
title_sort | creeping fat in crohn’s disease—surgical, histological, and radiological approaches |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381426/ https://www.ncbi.nlm.nih.gov/pubmed/37511642 http://dx.doi.org/10.3390/jpm13071029 |
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