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Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review

COVID-19 affects brain function, as deduced by the “brain fog” that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic diseas...

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Autores principales: Kotzalidis, Georgios D., Ferrara, Ottavia Marianna, Margoni, Stella, Ieritano, Valentina, Restaino, Antonio, Bernardi, Evelina, Fischetti, Alessia, Catinari, Antonello, Monti, Laura, Chieffo, Daniela Pia Rosaria, Simonetti, Alessio, Sani, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381510/
https://www.ncbi.nlm.nih.gov/pubmed/37511753
http://dx.doi.org/10.3390/jpm13071140
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author Kotzalidis, Georgios D.
Ferrara, Ottavia Marianna
Margoni, Stella
Ieritano, Valentina
Restaino, Antonio
Bernardi, Evelina
Fischetti, Alessia
Catinari, Antonello
Monti, Laura
Chieffo, Daniela Pia Rosaria
Simonetti, Alessio
Sani, Gabriele
author_facet Kotzalidis, Georgios D.
Ferrara, Ottavia Marianna
Margoni, Stella
Ieritano, Valentina
Restaino, Antonio
Bernardi, Evelina
Fischetti, Alessia
Catinari, Antonello
Monti, Laura
Chieffo, Daniela Pia Rosaria
Simonetti, Alessio
Sani, Gabriele
author_sort Kotzalidis, Georgios D.
collection PubMed
description COVID-19 affects brain function, as deduced by the “brain fog” that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR PTSD) AND COVID-19 AND (neuroimaging OR voxel OR VBM OR freesurfer OR structural OR ROI OR whole-brain OR hippocamp* OR amygd* OR “deep gray matter” OR “cortical thickness” OR caudate OR striatum OR accumbens OR putamen OR “regions of interest” OR subcortical)) OR (COVID-19 AND brain AND (voxel[ti] OR VBM[ti] OR magnetic[ti] OR resonance[ti] OR imaging[ti] OR neuroimaging[ti] OR neuroimage[ti] OR positron[ti] OR photon*[ti] OR PET[ti] OR SPET[ti] OR SPECT[ti] OR spectroscop*[ti] OR MRS[ti])), which produced 486 records and two additional records from other sources, of which 36 were found to be eligible. Alterations were identified and described and plotted against the ordinary PTSD imaging findings. Common elements were hypometabolism in the insula and caudate nucleus, reduced hippocampal volumes, and subarachnoid hemorrhages, while white matter hyperintensities were widespread in both PTSD and post-COVID-19 brain infection. The comparison partly supported our initial hypothesis. These data may contribute to further investigation of the effects of long COVID on brain structure and function.
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spelling pubmed-103815102023-07-29 Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review Kotzalidis, Georgios D. Ferrara, Ottavia Marianna Margoni, Stella Ieritano, Valentina Restaino, Antonio Bernardi, Evelina Fischetti, Alessia Catinari, Antonello Monti, Laura Chieffo, Daniela Pia Rosaria Simonetti, Alessio Sani, Gabriele J Pers Med Systematic Review COVID-19 affects brain function, as deduced by the “brain fog” that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR PTSD) AND COVID-19 AND (neuroimaging OR voxel OR VBM OR freesurfer OR structural OR ROI OR whole-brain OR hippocamp* OR amygd* OR “deep gray matter” OR “cortical thickness” OR caudate OR striatum OR accumbens OR putamen OR “regions of interest” OR subcortical)) OR (COVID-19 AND brain AND (voxel[ti] OR VBM[ti] OR magnetic[ti] OR resonance[ti] OR imaging[ti] OR neuroimaging[ti] OR neuroimage[ti] OR positron[ti] OR photon*[ti] OR PET[ti] OR SPET[ti] OR SPECT[ti] OR spectroscop*[ti] OR MRS[ti])), which produced 486 records and two additional records from other sources, of which 36 were found to be eligible. Alterations were identified and described and plotted against the ordinary PTSD imaging findings. Common elements were hypometabolism in the insula and caudate nucleus, reduced hippocampal volumes, and subarachnoid hemorrhages, while white matter hyperintensities were widespread in both PTSD and post-COVID-19 brain infection. The comparison partly supported our initial hypothesis. These data may contribute to further investigation of the effects of long COVID on brain structure and function. MDPI 2023-07-15 /pmc/articles/PMC10381510/ /pubmed/37511753 http://dx.doi.org/10.3390/jpm13071140 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Kotzalidis, Georgios D.
Ferrara, Ottavia Marianna
Margoni, Stella
Ieritano, Valentina
Restaino, Antonio
Bernardi, Evelina
Fischetti, Alessia
Catinari, Antonello
Monti, Laura
Chieffo, Daniela Pia Rosaria
Simonetti, Alessio
Sani, Gabriele
Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title_full Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title_fullStr Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title_full_unstemmed Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title_short Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review
title_sort are the post-covid-19 posttraumatic stress disorder (ptsd) symptoms justified by the effects of covid-19 on brain structure? a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381510/
https://www.ncbi.nlm.nih.gov/pubmed/37511753
http://dx.doi.org/10.3390/jpm13071140
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