Molecular and Phenotypic Changes in FLExDUX4 Mice

Facioscapulohumeral muscular dystrophy (FSHD) is caused by the aberrant expression of the double homeobox 4 (DUX4) gene. The FLExDUX4 mouse model carries an inverted human DUX4 transgene which has leaky DUX4 transgene expression at a very low level. No overt muscle pathology was reported before 16 w...

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Detalles Bibliográficos
Autores principales: Murphy, Kelly, Zhang, Aiping, Bittel, Adam J., Chen, Yi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381554/
https://www.ncbi.nlm.nih.gov/pubmed/37511653
http://dx.doi.org/10.3390/jpm13071040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381554/
https://www.ncbi.nlm.nih.gov/pubmed/37511653
http://dx.doi.org/10.3390/jpm13071040

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