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Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota

The regular administration of antibiotics is a public concern due to the prejudices of large population groups and the high frequency with which antimicrobial products are prescribed. The current study aimed to evaluate the in vitro effect of a new extract from Boletus edulis (BEE) on the human micr...

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Autores principales: Avram, Ionela, Pelinescu, Diana, Gatea, Florentina, Ionescu, Robertina, Barcan, Alexandru, Rosca, Razvan, Zanfirescu, Anca, Vamanu, Emanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381576/
https://www.ncbi.nlm.nih.gov/pubmed/37511858
http://dx.doi.org/10.3390/life13071481
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author Avram, Ionela
Pelinescu, Diana
Gatea, Florentina
Ionescu, Robertina
Barcan, Alexandru
Rosca, Razvan
Zanfirescu, Anca
Vamanu, Emanuel
author_facet Avram, Ionela
Pelinescu, Diana
Gatea, Florentina
Ionescu, Robertina
Barcan, Alexandru
Rosca, Razvan
Zanfirescu, Anca
Vamanu, Emanuel
author_sort Avram, Ionela
collection PubMed
description The regular administration of antibiotics is a public concern due to the prejudices of large population groups and the high frequency with which antimicrobial products are prescribed. The current study aimed to evaluate the in vitro effect of a new extract from Boletus edulis (BEE) on the human microbiota. One of the disadvantages of this extensive use is the disruption of the human microbiota, leading to potential negative health consequences. The in vitro evaluation of BEE consisted in determining its cytotoxicity, influence on the concentration of four types of cytokines (IL-6, IL-10, IL-1β, TNFα), and capacity to modulate the human microbiota after administering antibiotics. The latter was assessed by microbiome analysis and the evaluation of short-chain fatty acid synthesis (SCFAs). Simultaneously, the content of total polyphenols, the antioxidant capacity, and the compositional analysis of the extract (individual polyphenols composition) were determined. The results showed that BEE modulates the microbial pattern and reduces inflammatory progression. The data demonstrated antioxidant properties correlated with the increase in synthesizing some biomarkers, such as SCFAs, which mitigated antibiotic-induced dysbiosis without using probiotic products.
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spelling pubmed-103815762023-07-29 Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota Avram, Ionela Pelinescu, Diana Gatea, Florentina Ionescu, Robertina Barcan, Alexandru Rosca, Razvan Zanfirescu, Anca Vamanu, Emanuel Life (Basel) Article The regular administration of antibiotics is a public concern due to the prejudices of large population groups and the high frequency with which antimicrobial products are prescribed. The current study aimed to evaluate the in vitro effect of a new extract from Boletus edulis (BEE) on the human microbiota. One of the disadvantages of this extensive use is the disruption of the human microbiota, leading to potential negative health consequences. The in vitro evaluation of BEE consisted in determining its cytotoxicity, influence on the concentration of four types of cytokines (IL-6, IL-10, IL-1β, TNFα), and capacity to modulate the human microbiota after administering antibiotics. The latter was assessed by microbiome analysis and the evaluation of short-chain fatty acid synthesis (SCFAs). Simultaneously, the content of total polyphenols, the antioxidant capacity, and the compositional analysis of the extract (individual polyphenols composition) were determined. The results showed that BEE modulates the microbial pattern and reduces inflammatory progression. The data demonstrated antioxidant properties correlated with the increase in synthesizing some biomarkers, such as SCFAs, which mitigated antibiotic-induced dysbiosis without using probiotic products. MDPI 2023-06-30 /pmc/articles/PMC10381576/ /pubmed/37511858 http://dx.doi.org/10.3390/life13071481 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Avram, Ionela
Pelinescu, Diana
Gatea, Florentina
Ionescu, Robertina
Barcan, Alexandru
Rosca, Razvan
Zanfirescu, Anca
Vamanu, Emanuel
Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title_full Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title_fullStr Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title_full_unstemmed Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title_short Boletus edulis Extract—A New Modulator of Dysbiotic Microbiota
title_sort boletus edulis extract—a new modulator of dysbiotic microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381576/
https://www.ncbi.nlm.nih.gov/pubmed/37511858
http://dx.doi.org/10.3390/life13071481
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