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The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study
We investigated the association between mental disorders and the incidence rate of retinal vein occlusion (RVO) in young Korean adults. This nationwide cohort study included subjects aged 20–40 years who underwent the Korean National Health Examination between 2009 and 2012. The diagnoses of RVO and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381617/ https://www.ncbi.nlm.nih.gov/pubmed/37510989 http://dx.doi.org/10.3390/jcm12144874 |
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author | Lee, Ji-young Wang, Sheng-min Jeon, Seung-hee Kim, Min-hee Han, Kyung-do Roh, Young-jung |
author_facet | Lee, Ji-young Wang, Sheng-min Jeon, Seung-hee Kim, Min-hee Han, Kyung-do Roh, Young-jung |
author_sort | Lee, Ji-young |
collection | PubMed |
description | We investigated the association between mental disorders and the incidence rate of retinal vein occlusion (RVO) in young Korean adults. This nationwide cohort study included subjects aged 20–40 years who underwent the Korean National Health Examination between 2009 and 2012. The diagnoses of RVO and mental disorders were based on the International Classification of Diseases Tenth Revision codes. Multivariate Cox proportional hazard regression models were used to evaluate the objective. In total, 6,891,399 subjects were included at baseline and 6,597,803 subjects (mean age, 30.86 ± 4.99) were finally analyzed for a mean follow-up duration of 7.36 ± 1.13 years, with the mental disorders group followed for 7.27 ± 1.15 years and the non-diagnosed group for 7.37 ± 1.12 years. Among a total of 10,145 subjects diagnosed with RVO, 1304 had been diagnosed with mental disorders, while 8841 had not. Cumulative incidence of RVO demonstrated a substantially higher incidence probability in subjects with mental disorders (log-rank p < 0.0001). Mental disorders were associated with an increased incidence rate of RVO (hazard ratio [HR]: 1.268; 95% confidence interval; [CI]: 1.196–1.344). In the subgroup analysis, subjects with depression, sleep disorder, and anxiety disorder exhibited an increased risk of incidence of RVO in all regression models (all p < 0.001). In conclusion, mental disorders and the incidence rate of RVO were significantly positively correlated in a Korean nationwide population-based cohort study. These findings suggest that mental disorders may also be associated with the pathophysiology of RVO in young adults. |
format | Online Article Text |
id | pubmed-10381617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103816172023-07-29 The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study Lee, Ji-young Wang, Sheng-min Jeon, Seung-hee Kim, Min-hee Han, Kyung-do Roh, Young-jung J Clin Med Article We investigated the association between mental disorders and the incidence rate of retinal vein occlusion (RVO) in young Korean adults. This nationwide cohort study included subjects aged 20–40 years who underwent the Korean National Health Examination between 2009 and 2012. The diagnoses of RVO and mental disorders were based on the International Classification of Diseases Tenth Revision codes. Multivariate Cox proportional hazard regression models were used to evaluate the objective. In total, 6,891,399 subjects were included at baseline and 6,597,803 subjects (mean age, 30.86 ± 4.99) were finally analyzed for a mean follow-up duration of 7.36 ± 1.13 years, with the mental disorders group followed for 7.27 ± 1.15 years and the non-diagnosed group for 7.37 ± 1.12 years. Among a total of 10,145 subjects diagnosed with RVO, 1304 had been diagnosed with mental disorders, while 8841 had not. Cumulative incidence of RVO demonstrated a substantially higher incidence probability in subjects with mental disorders (log-rank p < 0.0001). Mental disorders were associated with an increased incidence rate of RVO (hazard ratio [HR]: 1.268; 95% confidence interval; [CI]: 1.196–1.344). In the subgroup analysis, subjects with depression, sleep disorder, and anxiety disorder exhibited an increased risk of incidence of RVO in all regression models (all p < 0.001). In conclusion, mental disorders and the incidence rate of RVO were significantly positively correlated in a Korean nationwide population-based cohort study. These findings suggest that mental disorders may also be associated with the pathophysiology of RVO in young adults. MDPI 2023-07-24 /pmc/articles/PMC10381617/ /pubmed/37510989 http://dx.doi.org/10.3390/jcm12144874 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Ji-young Wang, Sheng-min Jeon, Seung-hee Kim, Min-hee Han, Kyung-do Roh, Young-jung The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title | The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title_full | The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title_fullStr | The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title_full_unstemmed | The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title_short | The Risk of Retinal Vein Occlusion in Young Patients with Mental Disorders: A Nationwide Cohort Study |
title_sort | risk of retinal vein occlusion in young patients with mental disorders: a nationwide cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381617/ https://www.ncbi.nlm.nih.gov/pubmed/37510989 http://dx.doi.org/10.3390/jcm12144874 |
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