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Case Studies in Molecular Network-Guided Marine Biodiscovery
In reviewing a selection of recent case studies from our laboratory, we revealed some lessons learned and benefits accrued from the application of mass spectrometry (MS/MS) molecular networking in the field of marine sponge natural products. Molecular networking proved pivotal to our discovery of ma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381900/ https://www.ncbi.nlm.nih.gov/pubmed/37504944 http://dx.doi.org/10.3390/md21070413 |
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author | Khushi, Shamsunnahar Salim, Angela A. Capon, Robert J. |
author_facet | Khushi, Shamsunnahar Salim, Angela A. Capon, Robert J. |
author_sort | Khushi, Shamsunnahar |
collection | PubMed |
description | In reviewing a selection of recent case studies from our laboratory, we revealed some lessons learned and benefits accrued from the application of mass spectrometry (MS/MS) molecular networking in the field of marine sponge natural products. Molecular networking proved pivotal to our discovery of many new natural products and even new classes of natural product, some of which were opaque to alternate dereplication and prioritization strategies. Case studies included the discovery of: (i) trachycladindoles, an exceptionally rare class of bioactive indole alkaloid previously only known from a single southern Australia sample of Trachycladus laevispirulifer; (ii) dysidealactams, an unprecedented class of sesquiterpene glycinyl-lactam and glycinyl-imide from a Dysidea sp., a sponge genera often discounted as having been exhaustively studied; (iii) cacolides, an unprecedented family of sesterterpene α-methyl-γ-hydroxybutenolides from a Cacospongia sp., all too easily mischaracterized and deprioritized during dereplication as a well-known class of sponge sesterterpene tetronic acids; and (iv) thorectandrins, a new class of indole alkaloid which revealed unexpected insights into the chemical and biological properties of the aplysinopsins, one of the earliest and more extensively reported class of sponge natural products. |
format | Online Article Text |
id | pubmed-10381900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103819002023-07-29 Case Studies in Molecular Network-Guided Marine Biodiscovery Khushi, Shamsunnahar Salim, Angela A. Capon, Robert J. Mar Drugs Perspective In reviewing a selection of recent case studies from our laboratory, we revealed some lessons learned and benefits accrued from the application of mass spectrometry (MS/MS) molecular networking in the field of marine sponge natural products. Molecular networking proved pivotal to our discovery of many new natural products and even new classes of natural product, some of which were opaque to alternate dereplication and prioritization strategies. Case studies included the discovery of: (i) trachycladindoles, an exceptionally rare class of bioactive indole alkaloid previously only known from a single southern Australia sample of Trachycladus laevispirulifer; (ii) dysidealactams, an unprecedented class of sesquiterpene glycinyl-lactam and glycinyl-imide from a Dysidea sp., a sponge genera often discounted as having been exhaustively studied; (iii) cacolides, an unprecedented family of sesterterpene α-methyl-γ-hydroxybutenolides from a Cacospongia sp., all too easily mischaracterized and deprioritized during dereplication as a well-known class of sponge sesterterpene tetronic acids; and (iv) thorectandrins, a new class of indole alkaloid which revealed unexpected insights into the chemical and biological properties of the aplysinopsins, one of the earliest and more extensively reported class of sponge natural products. MDPI 2023-07-20 /pmc/articles/PMC10381900/ /pubmed/37504944 http://dx.doi.org/10.3390/md21070413 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Khushi, Shamsunnahar Salim, Angela A. Capon, Robert J. Case Studies in Molecular Network-Guided Marine Biodiscovery |
title | Case Studies in Molecular Network-Guided Marine Biodiscovery |
title_full | Case Studies in Molecular Network-Guided Marine Biodiscovery |
title_fullStr | Case Studies in Molecular Network-Guided Marine Biodiscovery |
title_full_unstemmed | Case Studies in Molecular Network-Guided Marine Biodiscovery |
title_short | Case Studies in Molecular Network-Guided Marine Biodiscovery |
title_sort | case studies in molecular network-guided marine biodiscovery |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381900/ https://www.ncbi.nlm.nih.gov/pubmed/37504944 http://dx.doi.org/10.3390/md21070413 |
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