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Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock

Although previous studies investigated the influence of cardiovascular risk (CVR) factors in patients with acute coronary syndrome, data concerning the effect of CVR factors on the prognosis of patients with cardiogenic shock (CS) is scarce. Consecutive patients with CS were prospectively included f...

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Autores principales: Forner, Jan, Schupp, Tobias, Weidner, Kathrin, Ruka, Marinela, Egner-Walter, Sascha, Behnes, Michael, Akin, Muharrem, Ayoub, Mohamed, Mashayekhi, Kambis, Akin, Ibrahim, Rusnak, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381971/
https://www.ncbi.nlm.nih.gov/pubmed/37510985
http://dx.doi.org/10.3390/jcm12144870
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author Forner, Jan
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Behnes, Michael
Akin, Muharrem
Ayoub, Mohamed
Mashayekhi, Kambis
Akin, Ibrahim
Rusnak, Jonas
author_facet Forner, Jan
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Behnes, Michael
Akin, Muharrem
Ayoub, Mohamed
Mashayekhi, Kambis
Akin, Ibrahim
Rusnak, Jonas
author_sort Forner, Jan
collection PubMed
description Although previous studies investigated the influence of cardiovascular risk (CVR) factors in patients with acute coronary syndrome, data concerning the effect of CVR factors on the prognosis of patients with cardiogenic shock (CS) is scarce. Consecutive patients with CS were prospectively included from 2019 to 2021. The prognosis of patients with “low CVR” (i.e., 0–1 CVR factors) was compared to patients with “high CVR” (i.e., 2–4 CVR factors) according to presence or absence of arterial hypertension, diabetes mellitus, hyperlipidaemia or smoking. The primary endpoint was 30-day all-cause mortality. Statistical analyses included Kaplan-Meier and Cox proportional regression analyses. 273 consecutive patients with CS were included. 28% presented with low CVR and 72% with high CVR. Within the entire study cohort, the risk of 30-day all-cause mortality did not differ between patients with high and low CVR (55% vs. 57%; log rank p = 0.727; HR = 0.942; 95% CI 0.663–1.338; p = 0.738). Even after multivariable adjustment, high CVR was not associated with an elevated risk of 30-day all-cause mortality (HR = 1.039; 95% CI 0.648–1.667; p = 0.873). The presence of arterial hypertension (55% vs. 58%; log rank p = 0.564; HR = 0.906; 95% CI 0.638–1.287; p = 0.582), diabetes mellitus (60% vs. 52%; log rank p = 0.215; HR = 1.213; 95% CI 0.881–1.671; p = 0.237) and a history of smoking (56% vs. 56%; log rank p = 0.725; HR = 0.945; 95% CI 0.679–1.315; p = 0.737) did not significantly influence short-term prognosis.. Only the absence of hyperlipidaemia significantly decreased the risk of all-cause mortality (65% vs. 51%; log rank p = 0.038; HR = 0.718; 95% CI 0.516–0.998; p = 0.049), which was no longer observed after multivariable adjustment (HR = 0.801; 95% CI 0.536–1.195; p = 0.277). In conclusion, neither the overall CVR nor individual CVR factors were associated with the risk of 30-day all-cause mortality in patients with CS.
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spelling pubmed-103819712023-07-29 Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock Forner, Jan Schupp, Tobias Weidner, Kathrin Ruka, Marinela Egner-Walter, Sascha Behnes, Michael Akin, Muharrem Ayoub, Mohamed Mashayekhi, Kambis Akin, Ibrahim Rusnak, Jonas J Clin Med Article Although previous studies investigated the influence of cardiovascular risk (CVR) factors in patients with acute coronary syndrome, data concerning the effect of CVR factors on the prognosis of patients with cardiogenic shock (CS) is scarce. Consecutive patients with CS were prospectively included from 2019 to 2021. The prognosis of patients with “low CVR” (i.e., 0–1 CVR factors) was compared to patients with “high CVR” (i.e., 2–4 CVR factors) according to presence or absence of arterial hypertension, diabetes mellitus, hyperlipidaemia or smoking. The primary endpoint was 30-day all-cause mortality. Statistical analyses included Kaplan-Meier and Cox proportional regression analyses. 273 consecutive patients with CS were included. 28% presented with low CVR and 72% with high CVR. Within the entire study cohort, the risk of 30-day all-cause mortality did not differ between patients with high and low CVR (55% vs. 57%; log rank p = 0.727; HR = 0.942; 95% CI 0.663–1.338; p = 0.738). Even after multivariable adjustment, high CVR was not associated with an elevated risk of 30-day all-cause mortality (HR = 1.039; 95% CI 0.648–1.667; p = 0.873). The presence of arterial hypertension (55% vs. 58%; log rank p = 0.564; HR = 0.906; 95% CI 0.638–1.287; p = 0.582), diabetes mellitus (60% vs. 52%; log rank p = 0.215; HR = 1.213; 95% CI 0.881–1.671; p = 0.237) and a history of smoking (56% vs. 56%; log rank p = 0.725; HR = 0.945; 95% CI 0.679–1.315; p = 0.737) did not significantly influence short-term prognosis.. Only the absence of hyperlipidaemia significantly decreased the risk of all-cause mortality (65% vs. 51%; log rank p = 0.038; HR = 0.718; 95% CI 0.516–0.998; p = 0.049), which was no longer observed after multivariable adjustment (HR = 0.801; 95% CI 0.536–1.195; p = 0.277). In conclusion, neither the overall CVR nor individual CVR factors were associated with the risk of 30-day all-cause mortality in patients with CS. MDPI 2023-07-24 /pmc/articles/PMC10381971/ /pubmed/37510985 http://dx.doi.org/10.3390/jcm12144870 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Forner, Jan
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Behnes, Michael
Akin, Muharrem
Ayoub, Mohamed
Mashayekhi, Kambis
Akin, Ibrahim
Rusnak, Jonas
Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title_full Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title_fullStr Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title_full_unstemmed Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title_short Effect of Cardiovascular Risk Factors on 30-Day All-Cause Mortality in Cardiogenic Shock
title_sort effect of cardiovascular risk factors on 30-day all-cause mortality in cardiogenic shock
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381971/
https://www.ncbi.nlm.nih.gov/pubmed/37510985
http://dx.doi.org/10.3390/jcm12144870
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