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Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review

Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity of these material...

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Detalles Bibliográficos
Autores principales: Baino, Francesco, Montazerian, Maziar, Verné, Enrica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382018/
https://www.ncbi.nlm.nih.gov/pubmed/37512268
http://dx.doi.org/10.3390/ma16144994
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author Baino, Francesco
Montazerian, Maziar
Verné, Enrica
author_facet Baino, Francesco
Montazerian, Maziar
Verné, Enrica
author_sort Baino, Francesco
collection PubMed
description Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity of these materials (especially bone-bonding and osteo-stimulatory properties) with the pro-angiogenic effect associated with the release of cobalt. Although the use and local delivery of Co(2+) ions into the body have raised some concerns about the possible toxic effects on living cells and tissues, important biological improvements have been highlighted both in vitro and in vivo. This review aims at providing a comprehensive overview of Co-releasing glasses, which find biomedical applications as various products, including micro- and nanoparticles, composites in combination with biocompatible polymers, fibers and porous scaffolds. Therapeutic applications in the field of bone repair, wound healing and cancer treatment are discussed in the light of existing experimental evidence along with the open issues ahead.
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spelling pubmed-103820182023-07-29 Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review Baino, Francesco Montazerian, Maziar Verné, Enrica Materials (Basel) Review Improving angiogenesis is the key to the success of most regenerative medicine approaches. However, how and to which extent this may be performed is still a challenge. In this regard, cobalt (Co)-doped bioactive glasses show promise being able to combine the traditional bioactivity of these materials (especially bone-bonding and osteo-stimulatory properties) with the pro-angiogenic effect associated with the release of cobalt. Although the use and local delivery of Co(2+) ions into the body have raised some concerns about the possible toxic effects on living cells and tissues, important biological improvements have been highlighted both in vitro and in vivo. This review aims at providing a comprehensive overview of Co-releasing glasses, which find biomedical applications as various products, including micro- and nanoparticles, composites in combination with biocompatible polymers, fibers and porous scaffolds. Therapeutic applications in the field of bone repair, wound healing and cancer treatment are discussed in the light of existing experimental evidence along with the open issues ahead. MDPI 2023-07-14 /pmc/articles/PMC10382018/ /pubmed/37512268 http://dx.doi.org/10.3390/ma16144994 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Baino, Francesco
Montazerian, Maziar
Verné, Enrica
Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title_full Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title_fullStr Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title_full_unstemmed Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title_short Cobalt-Doped Bioactive Glasses for Biomedical Applications: A Review
title_sort cobalt-doped bioactive glasses for biomedical applications: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382018/
https://www.ncbi.nlm.nih.gov/pubmed/37512268
http://dx.doi.org/10.3390/ma16144994
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